The former Hewlett-Packard CEO ran unsuccessfully as a Republican against Sen. Boxer in 2010.
GOP Presidential Primary
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The former Arkansas governor appears to be preparing for a 2016 bid.
“It really is an ordeal to be part of public life," Paul said.
New Mexico Gov. Susana Martinez says she still isn't interested in joining a national ticket as a vice presidential candidate, even if her ally New Jersey Gov. Chris Christie were to secure the Republican nomination.
The former Florida governor also described Republican efforts to defund Obamacare as unrealistic.
Paul reversed his earlier position when, because of the Clinton programs, he questioned whether Republicans could get a "fair shake."
Sen. Marco Rubio (Fla.) voted in favor, while Sens. Rand Paul (Ky.) and Ted Cruz (Texas) opposed it.
Many Republicans warn he'll have to learn to stay on message if hopes to launch a credible campaign in 2016.
Paul had hoped to win enough delegates to be nominated and secure a speaking slot at the national convention.