Heidi Cruz, the wife of Republican presidential hopeful Ted CruzRafael (Ted) Edward CruzWhatever you think the Alabama special election means, you’re probably wrong This week: Congress gets ball rolling on tax reform Week ahead: Senators work toward deal to fix ObamaCare markets MORE, on Wednesday spoke out about Donald TrumpDonald John TrumpIvanka Trump pens op-ed on kindergartners learning tech Bharara, Yates tamp down expectations Mueller will bring criminal charges Overnight Cybersecurity: Equifax security employee left after breach | Lawmakers float bill to reform warrantless surveillance | Intel leaders keeping collusion probe open MORE’s Twitter threats against her.

“Most of the things Donald Trump says have no basis in reality,” Heidi Cruz told reporters at a campaign stop in Wisconsin. “We are not worried. We’re focusing on our campaign, and we’re going to continue to do that.”

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She was responding after Trump threatened to “spill the beans” on her in a late-night tweet Tuesday.

Trump was angry that an anti-Trump super-PAC used an image of his wife, Melania, posing nude for an ad in Utah before Tuesday's caucuses.

Cruz noted that the ad didn’t come from the Cruz campaign, touting her husband's “positive, optimistic” agenda.

“We have run our campaign with the principles that Ted and I believe in,” she said. “A lot of the things that are done from time to time are not from our campaign.”

The ad shows a photo of Melania Trump posing nude for GQ Magazine with the words “Meet Melania Trump. Your next first lady.” It was paid for by Make America Awesome, an anti-Trump super PAC.

Ted Cruz had earlier in the day criticized Trump's tweet, saying such attacks should be beneath him.

“It reveals a lot about character,” Cruz told CNN's Chris Cuomo. “It reveals a lot about class, that Donald’s instinct is to try to attack my wife and sully her.” 

- Updated at 12:17 p.m.