Republican presidential candidate Ted CruzRafael (Ted) Edward CruzSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea GOP state lawmakers meet to plan possible constitutional convention MORE on Thursday angrily slammed rival Donald TrumpDonald John TrumpBiden slams Trump over golf gif hitting Clinton Trump Jr. declines further Secret Service protection: report Report: Mueller warned Manafort to expect an indictment MORE for dragging Cruz's wife into the campaign with a series of attacks.

"It's not easy to tick me off. I don't get angry often. But you mess with my wife, you mess with my kids, that'll do it every time," Cruz said in Wisconsin.

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"Donald, you're a sniveling coward. Leave Heidi the hell alone."

Trump first attacked Heidi Cruz on Tuesday night with a tweet threatening to "spill the beans" about her. Trump was responding to an ad from an anti-Trump super-PAC that featured Trump's wife posing nude.

Trump intensified the attacks by sharing a tweet late Wednesday night with an image comparing his wife, Melania, a former model, to Cruz's wife and stating, "A picture is worth a thousand words."

Asked whether he would support Trump if he gets the nomination, Cruz avoided the question.

"I'm going to beat him for the nomination," he said. 

"Donald Trump will not be the nominee," he continued to repeat when pressed.