Both ads seek to personalize bigger issues with the program.
"I received notice that my current insurance was no longer qualified. I've had three heart attacks in the last six years. Healthcare is something that's essential. My life depends on it," says Randy Westby in the ad. "Congressman Nolan, ObamaCare needs to be repealed. It was a big lie."
The other ad is the latest version of one the group has previously used elsewhere, featuring a soft-spoken woman saying ObamaCare "just doesn't work."
"Healthcare isn't about politics, it's about people," she says. "And millions of people have lost their health insurance, millions can't see their own doctors, and millions are paying more and getting less."
Both Nolan and Kuster are freshmen from swing districts and are facing competitive reelection races.
The ads are the latest salvo in Americans for Prosperity's war against ObamaCare after spending $16 million on ads in the last few months. The two new ads have a combined $600,000 behind them.