"Thinking about college? Think again. Kyrsten Sinema voted to raise student loan rates," one version of the ad says.
The ads come a day after the Democratic Congressional Campaign Committee rolled out a paid Twitter campaign attacking House Republicans on the same issue.
Student loan rates are set to double from 3.4 percent to 6.8 percent on July 1 if Congress can't agree on a plan.
House Republicans have pushed a plan that would allow varying interest rates based on current market conditions, with a cap at 8.5 percent.
Both sides are looking to score political points off the stalemate — and leverage the issue to appeal to younger voters and their parents and argue that the other party doesn't have their interests at heart.