"Although I have decided not to run for office at this time, I look forward to pursuing other avenues that will allow me to continue to be politically involved," she said in an email to supporters, according to the Post-Standard.
"The details of what exactly the future holds in that regard remain to be seen, but I am excited to see what the next chapter holds," she added.
Buerkle would've been in for her third rematch with Maffei, after defeating him for the seat by less than a thousand votes in 2010, and then losing to him by about five percentage points in 2012.
New York's 24th congressional district became more favorable for Democrats after a federal judge redrew the state's district maps, and Maffei is now expected to have an easier path to reelection.
Two other Republicans, Onondaga County Comptroller Robert Antonacci and Syracuse City Council member Rick Guy, are also considering challenging Maffei, according to the Post-Standard.