Six-term Rep. Ciro Rodriguez (D-Texas) lost his bid for reelection Tuesday at the hands of Republican challenger Francisco Canseco.
The South Texas district was one of the races that looked relatively safe for Democrats at the start of the cycle, but moved into the tossup column over the summer.
Republican Jaime Herrera captured the district held by Rep. Brian Baird (D-Wash.) for six terms Tuesday. The Republican won a narrow victory over Democrat Denny Heck, who received a high profile campaign visit from Vice President Joe Biden in the final weeks of the campaign.
The AP is no longer calling Georgia's second district for Republican Mike Keown. Earlier in the evening, the AP reported nine-term Rep. Sanford Bishop (D) had lost but, with additional votes counted, Bishop holds a slim lead.
Republican Patrick Meehan won the race to fill the seat left vacant by Rep. Joe Sestak (D-Pa.), who embarked on a failed run for Senate.
Meehan defeated Democrat Bryan Lentz by a solid margin Tuesday in another race where Democrats were accused of propping up a Tea Party challenger.
Lentz's campaign admitted that it helped James Schneller get on the ballot in the district. Schneller ended up winning less than 2 percent of the total vote.
Nancy Pelosi (D-Calif.) may have lost the speaker's gavel but she's still a member of Congress. She easily defeated Republican John Dennis. She has given no indication of whether she intended to stay as Democratic leader in the minority, but there was widespread speculation that she would step aside in favor of her top lieutenant, Majority Leader Steny Hoyer (Md.).
There wasn't a single House Democrat who was more forceful in distancing himself from House Speaker Nancy Pelosi (D-Calif.) in 2010, but it didn't help freshman Rep. Bobby Bright (D-Ala.) hang onto his seat.
Republican Martha Roby defeated Bright narrowly Tuesday, winning with just over 51 percent of the vote.
In response to the question of whether he would support Pelosi again as Speaker, Bright said at a campaign event back in September, "Heck, she might even get sick and die."
The Democrat, who occupied one of the most conservative House districts in the nation, also ran a campaign ad bragging that he voted with House Minority Leader John Boehner (R-Ohio) 80 percent of the time.
Democrats retained two open seats in Massachusetts and Rhode
Island, including the district held by retiring Rep. Patrick Kennedy R.I., son
of the late Sen. Edward Kennedy (Mass.).
In Rhode Island’s 1st district, Providence Mayor David
Cicilline (D) defeated state Rep. John Loughlin II (R).
In Massachusetts, Democrat Bill Keating defeated GOP state
Rep. Jeff Perry to win the seat vacated by retiring Rep. William Delahunt (D) in
the state’s 10th district.
Republican Ben Quayle, the son of former Vice President Dan Quayle, won Arizona's third district, keeping the seat in GOP hands.
And freshman Rep. Ann Kirkpatrick (D) lost to Republican Paul Gosar.
Rep. John Dingell (D-Mich.), who in his 27th term is the longest serving member of Congress, survived an electoral scare from Republican Rob Steele Tuesday.
Given the depth of the GOP wave in the House Tuesday, even Dingell's seat was ripe for the taking.
But the longtime incumbent, who was one of the symbolic faces of healthcare reform in the House, had 53 percent of the vote when the race was called in his favor.
Rep. Steve Kagen (D-Wis.) lost his bid for reelection Tuesday to Republican Reid Ribble.
Kagen infamously made the claim at a gathering of liberal activists in 2007 that he confronted Karl Rove in a White House bathroom.
This was the second election cycle that Kagen found himself in the crosshairs of national Republicans.