Rep. Paul RyanPaul Davis RyanHillicon Valley: Mnuchin urges antitrust review of tech | Progressives want to break up Facebook | Classified election security briefing set for Tuesday | Tech CEOs face pressure to appear before Congress Feehery: An opening to repair our broken immigration system GOP chairman in talks with 'big pharma' on moving drug pricing bill MORE (R-Wis.) called for GOP unity at the annual Conservative Political Action Conference, asking the grassroots crowd to give Republican leaders the "benefit of the doubt."

Ryan, the 2012 vice presidential nominee, is viewed both as a potential 2016 White House candidate and future House Speaker. But speaking to the Tea Party-dominated crowd, his speech seemed designed more to defend Republican leaders' decisionmaking and build support within the House conference than grow his appeal with the base.

"I don't see this great divide in our party. What I see is a vibrant debate. Yes we have our disagreements. Yes they can get a little passionate," Ryan said. "[But] for the most part, these disagreements have not been over policies or principles — they've been over tactics. So I think we should give each other the benefit of the doubt."

The speech stood in contrast to Sen. Ted Cruz's (R-Texas) attack just minutes earlier on the Republican establishment, which drew louder applause from the activist crowd. 

Ryan, who recently released a report slamming government programs designed to alleviate poverty, blasted Democrats' plans to help the poor.

"The left is making a big mistake here. What they're offering people is a full stomach and an empty soul. The American people want more than that," he said.