Sen. Marco RubioMarco Antonio RubioOvernight Defense: Tillerson, Trump deny report of rift | Tillerson says he never considered resigning | Trump expresses 'total confidence' in secretary | Rubio asks Army to kick out West Point grad Rubio asks Army to kick out West Point grad with pro-communist posts GOP establishment doubts Bannon’s primary powers MORE (R-Fla.) believes he can beat Hillary ClintonHillary Diane Rodham ClintonChris Murphy’s profile rises with gun tragedies DNC, RNC step up cyber protections Gun proposal picks up GOP support MORE in the race for the 2016 presidency.

"Multiple people can beat her. Hillary Clinton is not unbeatable," the GOP presidential hopeful told radio host Hugh Hewitt in an interview Friday.

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When asked whether he's concerned about Clinton's extensive foreign policy background if he or another Republican candidate ran against her, Rubio quickly slammed the potential Democratic frontrunner.

"I'd ask her: You were the secretary of State during the first four years of the Obama administration, name one significant foreign policy achievement, now or after you left?", he said.

"The reset with Russia has been a disaster, the Middle East is more unstable today than it's been in I don't know when, our relationships with Latin America and democracy have deteriorated…our partners around the world view us as less reliable."

The Florida lawmaker also weighed in on Lebron James' surprise move back to the Cleveland Cavaliers after four seasons with the Miami Heat.

"I read the article he wrote in Sports Illustrated and it's actually very compelling. And I have a lot of respect," he said.

"The way I view it, he gave us four extraordinary years in Miami, a very special experience and on a personal note he allowed me, along with his teammates, to share with my sons memories they'll treasure for the rest of their lives."