Sen. Lindsey GrahamLindsey Olin GrahamDurbin: I had 'nothing to do' with Curbelo snub Republicans jockey for position on immigration Overnight Health Care: House passes 20-week abortion ban | GOP gives ground over ObamaCare fix | Price exit sets off speculation over replacement MORE (S.C.) blasted fellow Republican presidential candidate Donald TrumpDonald John TrumpIvanka Trump pens op-ed on kindergartners learning tech Bharara, Yates tamp down expectations Mueller will bring criminal charges Overnight Cybersecurity: Equifax security employee left after breach | Lawmakers float bill to reform warrantless surveillance | Intel leaders keeping collusion probe open MORE on Monday night, calling the businessman a "jackass" for his comments on Sen. John McCainJohn Sidney McCainRubio asks Army to kick out West Point grad with pro-communist posts The VA's woes cannot be pinned on any singular administration Overnight Defense: Mattis offers support for Iran deal | McCain blocks nominees over Afghanistan strategy | Trump, Tillerson spilt raises new questions about N. Korea policy MORE's (R-Ariz.) war record.

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"What he said about John, I think, was offensive. He's becoming a jackass at a time when we need to have a serious debate about the future of the party and the country," Graham said on CNN’s "Erin Burnett OutFront."

"This is a line he's crossed, and this is the beginning of the end of Donald Trump. ... I am really pissed," Graham added.

Graham repeated his criticism of Trump on Tuesday morning, saying he didn't think there was "a market for slandering POWs" in the Republican Party.

"I don’t care if he drops out," Graham said on "CBS This Morning," after a top Iowa newspaper called on Trump to drop out of the race in the wake of his remarks.

"Stay in the race, just stop being a jackass. You don’t have to run for president and be the world’s biggest jackass — that’s not your choices," Graham said on CBS.

Trump caught widespread flak over the weekend for questioning McCain's status as a war hero, saying that he preferred those who did not get captured. He has since attempted to clarify those remarks.

McCain, who was held as a prisoner of war during Vietnam for nearly six years, brushed off the comments earlier Monday, saying Trump might owe an apology to other POWs.

Graham, a close friend of McCain's, is a long shot for the White House in an extremely crowded GOP field, but has sought to make national security a primary focus of the 2016 race.

Updated at 10:16 a.m.