White House hopeful Marco RubioMarco Antonio RubioCongress faces growing health care crisis in Puerto Rico The Hill's 12:30 Report Colbert mocks Trump for sipping water during speech on Asia trip MORE ripped rival Ted CruzRafael (Ted) Edward CruzTexas Republicans slam White House over disaster relief request Dem rep: Trump disaster aid request is 'how you let America down again' Moore endorsements disappear from campaign website MORE at Saturday's presidential debate for a "pattern" of telling lies, particularly about immigration reform.

"This is a disturbing pattern now. For a number of weeks Ted Cruz has just been telling lies," Rubio said. "He's lying about all sorts of things and now he's just making things up." 

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The Florida senator said that Cruz had lied "about Ben Carson in Iowa," referring to the Carson campaign's accusations that Cruz's campaign spread false rumors during the caucuses that the retired neurosurgeon was dropping out of the presidental race. 
 
Rubio's comments came as he and the Texas Republican battled over their stance in a 2013 fight in the Senate over a wide-ranging immigration reform bill. 
  
Cruz has repeatedly knocked Rubio for working with Democrats, calling the "Gang of Eight" bill the "Rubio-Schumer amnesty plan," referring to Sen. Charles SchumerCharles (Chuck) Ellis SchumerJuan Williams: The politics of impeachment Texas Republicans slam White House over disaster relief request Dem rep: Trump disaster aid request is 'how you let America down again' MORE (D-N.Y.), who is expected to be the next Democratic leader. 
 
"The question for anyone on illegal immigration, is where were you in that fight," Cruz added. 
 
Rubio, however, has pointed to amendments that the Texas senator pushed that removed a path to citizenship from the bill but kept work permits.
 
Asked about his tactics on the Senate's immigration bill, which ultimately stalled in the House, Cruz has said that the amendments were meant to expose Democrats' "bluff" and ultimately undermine the Gang of Eight bill.
 
Rubio wasn't alone at the South Carolina event in accusing Cruz of lying. Donald TrumpDonald John TrumpO’Malley tells Dems not to fear Trump Right way and wrong way Five things to know about the elephant trophies controversy MORE also said Cruz "is the single biggest liar. ...This guy will say anything."