Sen. Lindsey GrahamLindsey GrahamRomney should endorse Clinton Graham: I'm still not supporting Trump North Korean official calls Trump idea of meeting 'nonsense' MORE (R-S.C.) is remaining tight-lipped about whether he would vote for Donald TrumpDonald TrumpClinton: Trump wanted to profit off 'people's misery' Trump: I’ll take ‘close to 40 percent’ of Sanders fans Trump surrogate: ‘Even Bill Clinton chose other women’ over Hillary MORE if the billionaire were to become the Republican presidential nominee.
"I'll cross that bridge when I get there, but we'll lose," he said when asked if he would vote for Trump as GOP nominee.
"No, we won't lose," Graham added. "We'll get slaughtered."
Graham's comments come after Trump carried more than 45 percent of the vote in Tuesday night's Nevada Republican caucuses.
Asked about Trump's win, the South Carolina senator, himself a presidential contender this election cycle, said he thinks the real estate mogul "has momentum," and that Republicans have until early March to try to stop him from becoming the nominee.
Graham has been one of Trump's most vocal critics, both during his own bid and as a surrogate for former Florida Gov. Jen Bush, who recently ended his White House run.
While Trump has yet to pick up a single Senate endorsement and many vulnerable lawmakers are wary of tying themselves to the GOP front-runner, Republican senators have publicly stuck with the strategy that they'll support the eventual nominee.
Trump picked up his first two congressional endorsements on Wednesday, both from the House.
Graham has given little indication he'll endorse another candidate and said Wednesday that he was "disappointed" Sen. Marco RubioMarco RubioNew Mexico GOP gov. won’t attend home-state Trump rally Rubio: 'It’s not that we lost, it’s that Donald Trump won’ Santorum endorses Trump after 'long heart-to-heart' MORE (R-Fla.) isn't a stronger challenge to Trump.
Rubio came in second place in the Nevada caucuses behind Trump.