Sen. Lindsey GrahamLindsey GrahamTrump on primary rivals who don't back him: 'I don't know how they live with themselves' The Trail 2016: Who is really winning? Graham: GOP Senate could rein in Clinton White House MORE (R-S.C.) is remaining tight-lipped about whether he would vote for Donald TrumpDonald TrumpConway says she'll talk to Trump about press safety Helen Mirren gives advice for being a ‘nasty woman’ Gingrich goes off on Megyn Kelly over Trump allegations: 'You are fascinated with sex' MORE if the billionaire were to become the Republican presidential nominee.
"I'll cross that bridge when I get there, but we'll lose," he said when asked if he would vote for Trump as GOP nominee.
"No, we won't lose," Graham added. "We'll get slaughtered."
Graham's comments come after Trump carried more than 45 percent of the vote in Tuesday night's Nevada Republican caucuses.
Asked about Trump's win, the South Carolina senator, himself a presidential contender this election cycle, said he thinks the real estate mogul "has momentum," and that Republicans have until early March to try to stop him from becoming the nominee.
Graham has been one of Trump's most vocal critics, both during his own bid and as a surrogate for former Florida Gov. Jen Bush, who recently ended his White House run.
While Trump has yet to pick up a single Senate endorsement and many vulnerable lawmakers are wary of tying themselves to the GOP front-runner, Republican senators have publicly stuck with the strategy that they'll support the eventual nominee.
Trump picked up his first two congressional endorsements on Wednesday, both from the House.
Graham has given little indication he'll endorse another candidate and said Wednesday that he was "disappointed" Sen. Marco RubioMarco RubioThe Trail 2016: An important lesson in geography Clinton takes aim at Rubio in Florida rally Dem Senate hopeful dodges leaked Clinton emails at debate MORE (R-Fla.) isn't a stronger challenge to Trump.
Rubio came in second place in the Nevada caucuses behind Trump.