Marco RubioMarco Antonio RubioRubio heckled by protestors outside immigration detention facility Bill to protect work licenses of student loan debtors is welcome development Political figures pay tribute to Charles Krauthammer MORE ridiculed Donald TrumpDonald John TrumpGOP lawmakers preparing to vote on bill allowing migrant children to be detained longer than 20 days: report Wasserman Schultz: Infants separated from their parents are in Florida immigrant shelters Ex-White House ethics chief: Sarah Sanders tweet violates ethics laws MORE's approach to finding Middle East peace, saying that Israeli-Palestinian talks are not like a real estate deal.

"The Palestinians are not a real estate deal, Donald," the White House contender said in Thursday night's CNN Republican debate in Houston.

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Rubio and Ted CruzRafael (Ted) Edward CruzSenate left in limbo by Trump tweets, House delays The Hill's Morning Report — Sponsored by PhRMA — Immigration drama grips Washington Senate Gang of Four to meet next week on immigration MORE both hit the billionaire businessman for saying that he would be a neutral broker in peace negotiations between the Israelis and the Palestinians.

Both Rubio and Cruz say they would stand unequivocally with Israel, while the party front-runner argues that neutrality is required to make what would be "probably the toughest deal of any kind."

"A deal is a deal," Trump replied, when Rubio made the point that Middle East peace talks had nothing to do with negotiating real estate.

Rubio hit back: "A deal is not a deal when you're dealing with terrorists. Have you ever negotiated with terrorists?"

Trump, who was under attack from the Florida senator all night, replied, "You are not a negotiator. And with your thinking you will never bring peace."

"Donald might be able to build condos in the Palestinian areas, but ... this is not a real estate deal," Rubio said to close the exchange.