Marco RubioMarco Antonio RubioGOP looks to injure Nelson over Russia comments Rubio’s pro-family, conservative family leave policy promotes stability Dems make history in Tuesday's primaries MORE ridiculed Donald TrumpDonald John TrumpNFL players stand in tunnel during anthem, extending protests 12 former top intel officials blast Trump's move to revoke Brennan's security clearance NYT: Omarosa believed to have as many as 200 tapes MORE's approach to finding Middle East peace, saying that Israeli-Palestinian talks are not like a real estate deal.

"The Palestinians are not a real estate deal, Donald," the White House contender said in Thursday night's CNN Republican debate in Houston.

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Rubio and Ted CruzRafael (Ted) Edward CruzBeto O’Rourke: Term limits can help keep politicians from turning into a--holes Election Countdown: GOP worries House majority endangered by top of ticket | Dems make history in Tuesday's primaries | Parties fight for Puerto Rican vote in Florida | GOP lawmakers plan 'Freedom Tour' Former spokeswoman defends Trump calling Omarosa ‘dog’: He’s called men dogs MORE both hit the billionaire businessman for saying that he would be a neutral broker in peace negotiations between the Israelis and the Palestinians.

Both Rubio and Cruz say they would stand unequivocally with Israel, while the party front-runner argues that neutrality is required to make what would be "probably the toughest deal of any kind."

"A deal is a deal," Trump replied, when Rubio made the point that Middle East peace talks had nothing to do with negotiating real estate.

Rubio hit back: "A deal is not a deal when you're dealing with terrorists. Have you ever negotiated with terrorists?"

Trump, who was under attack from the Florida senator all night, replied, "You are not a negotiator. And with your thinking you will never bring peace."

"Donald might be able to build condos in the Palestinian areas, but ... this is not a real estate deal," Rubio said to close the exchange.