Sen. Marco RubioMarco RubioSenators introduce new Iran sanctions Senate intel panel has not seen Nunes surveillance documents: lawmakers With no emerging leaders, no clear message, Democrats flounder MORE (Fla.) is attacking rival Donald TrumpDonald TrumpBiden: I regret not running for president De Blasio blames Trump for 'dynamic of hatred' in US Dem to Trump: 'You truly are an evil man' MORE over one of his biggest weaknesses: his short fingers. 

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Rubio pointed out Trump’s “small hands” in comparison to the billionaire’s height at a campaign rally Sunday night. 

“You know what they say about men with small hands … you can’t trust 'em!” Rubio said.

Comments on Trump’s fingers have been known to set him off. 

In a November 2015 column for Vanity Fair, editor Graydon Carter detailed how the Republican front-runner responds to criticism about his fingers. 

“Just to drive him a little bit crazy, I took to referring to him as a ‘short-fingered vulgarian’ in the pages of Spy magazine,” Carter wrote. “That was more than a quarter of a century ago.” 

In 1988, Spy magazine referred to Trump as the "short-fingered vulgarian" in nearly every story. 

Trump defended himself in the New York Post, saying, “My fingers are long and beautiful, as, has been well-documented, are various other parts of my body.” 

Carter wrote that he still receives occasional photos from Trump in response to the criticism decades ago.

“On all of [the photos] he has circled his hand in gold Sharpie in a valiant effort to highlight the length of his fingers,” Carter said. “I almost feel sorry for the poor fellow because, to me, the fingers still look abnormally stubby.” 

The most recent photo arrived in 2015, before Trump announced he was running for president. 

“Like the other packages, this one included a circled hand and the words, also written in gold Sharpie: ‘See not so short!’ I sent the picture back … with a note attached saying, ‘Actually, quite short.’ 

“Which I can only assume gave him fits,” Carter wrote.