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CPAC has long been a stopping point for GOP presidential aspirants. Rubio, who has spoken at previous CPACs in previous years, is seen as a likely contender for the nomination.

"My friend Marco RubioMarco RubioWill Republicans stand up to the NRA's insurrection rhetoric? The Hill's Whip List: Senate ObamaCare repeal bill Ivanka Trump turns to House GOP on paid family leave MORE has quickly become one of our nation's most prominent conservative leaders," American Conservative Union Chairman Al Cardenas said in the release announcing the news. "Sen. Rubio's participation will serve as motivation to CPAC attendees and conservatives across the country to take action and bring our country back on track."

Rep. Paul RyanPaul RyanPaul Ryan: ‘Beautiful day’ to catch up with Bono Healthcare spending: the elephant in the tax reform room Overnight Healthcare: Latest on Senate healthcare bill | Four conservatives say they'll oppose | Obama slams bill | Health groups offer scathing criticism MORE (R-Wis.) is already scheduled to speak at the event, as is former Sen. Rick Santorum (R-Pa.).

The three-day event, in its 40th year, will be held in mid-March.