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CPAC has long been a stopping point for GOP presidential aspirants. Rubio, who has spoken at previous CPACs in previous years, is seen as a likely contender for the nomination.

"My friend Marco RubioMarco RubioSenators introduce new Iran sanctions Senate intel panel has not seen Nunes surveillance documents: lawmakers With no emerging leaders, no clear message, Democrats flounder MORE has quickly become one of our nation's most prominent conservative leaders," American Conservative Union Chairman Al Cardenas said in the release announcing the news. "Sen. Rubio's participation will serve as motivation to CPAC attendees and conservatives across the country to take action and bring our country back on track."

Rep. Paul RyanPaul RyanDan Rather: Failure to repeal ObamaCare most 'staggering loss' so early in a term Sunday shows preview: Aftermath of failed healthcare bill GOP lawmaker: Time to work with Dems on healthcare MORE (R-Wis.) is already scheduled to speak at the event, as is former Sen. Rick Santorum (R-Pa.).

The three-day event, in its 40th year, will be held in mid-March.