Former Secretary of State Hillary ClintonHillary Rodham ClintonIt’s time to come together to improve our healthcare system Press: Hillary's doomed bid Trump’s first 100 days saw liberal media derangement reach new heights MORE leads three potential 2016 Republican presidential contenders in a new poll.

In the new Quinnipiac poll of registered voters nationwide, New Jersey Gov. Chris Christie (R) fares the best against Clinton, taking 37 percent support to her 45 percent support.

But against the other two potential Republican candidates tested, Sen. Marco RubioMarco RubioTop Trump officials push border wall as government shutdown looms Rubio defends Trump: 'This whole flip-flop thing is a political thing' Rubio: Shutdown would have 'catastrophic impact' on global affairs MORE (R-Fla.) and Rep. Paul RyanPaul RyanOvernight Tech: Dem wants to see FCC chief's net neutrality plans | New agency panel on telecom diversity | Trump calls NASA astronaut Poll: Disapproval growing of Paul Ryan, GOP Congress Overnight Finance: Trump wants 15 percent corporate rate | GOP tax team huddles with Trump aides | Shutdown watch over border wall MORE (R-Wis.), Clinton takes double-digit leads, with 50 percent support to Ryan's 38 percent support and 50 percent to Rubio's 34 percent.

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Clinton is reportedly considering running in 2016, and Democrats say that if she jumped in the race, she'd likely clear the field.

But a handful of other Democrats, including Vice President Biden and New York Gov. Andrew Cuomo, are also considering a run.

Quinnipiac tested both Biden and Cuomo against the three Republicans, neither of whom are able to topple Christie.

The New Jersey governor leads Biden by 3 percentage points, with 43 percent support to Biden's 40 percent support, while Biden has the same edge against Ryan, with 45 percent support to Ryan's 42 percent. Biden leads Rubio by 7 percentage points.

And Christie takes a double-digit lead over Cuomo, who seems to suffer from a lack of name recognition, as he holds the highest percentage of undecided respondents in his match-ups. Ryan, too, leads Cuomo, by 5 percentage points, while Rubio ties him, both with 37 percent support.

Quinnipiac University surveyed 1,944 registered voters nationwide from Feb. 27 to March 4, and the poll has a margin of error of 2.2 percentage points.