Former Secretary of State Hillary ClintonHillary Diane Rodham ClintonChris Murphy’s profile rises with gun tragedies DNC, RNC step up cyber protections Gun proposal picks up GOP support MORE leads three potential 2016 Republican presidential contenders in a new poll.

In the new Quinnipiac poll of registered voters nationwide, New Jersey Gov. Chris Christie (R) fares the best against Clinton, taking 37 percent support to her 45 percent support.

But against the other two potential Republican candidates tested, Sen. Marco RubioMarco Antonio RubioOvernight Defense: Tillerson, Trump deny report of rift | Tillerson says he never considered resigning | Trump expresses 'total confidence' in secretary | Rubio asks Army to kick out West Point grad Rubio asks Army to kick out West Point grad with pro-communist posts GOP establishment doubts Bannon’s primary powers MORE (R-Fla.) and Rep. Paul RyanPaul RyanThe Hill Interview: Budget Chair Black sticks around for now Gun proposal picks up GOP support GOP lawmaker Tim Murphy to retire at end of term MORE (R-Wis.), Clinton takes double-digit leads, with 50 percent support to Ryan's 38 percent support and 50 percent to Rubio's 34 percent.

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Clinton is reportedly considering running in 2016, and Democrats say that if she jumped in the race, she'd likely clear the field.

But a handful of other Democrats, including Vice President Biden and New York Gov. Andrew Cuomo, are also considering a run.

Quinnipiac tested both Biden and Cuomo against the three Republicans, neither of whom are able to topple Christie.

The New Jersey governor leads Biden by 3 percentage points, with 43 percent support to Biden's 40 percent support, while Biden has the same edge against Ryan, with 45 percent support to Ryan's 42 percent. Biden leads Rubio by 7 percentage points.

And Christie takes a double-digit lead over Cuomo, who seems to suffer from a lack of name recognition, as he holds the highest percentage of undecided respondents in his match-ups. Ryan, too, leads Cuomo, by 5 percentage points, while Rubio ties him, both with 37 percent support.

Quinnipiac University surveyed 1,944 registered voters nationwide from Feb. 27 to March 4, and the poll has a margin of error of 2.2 percentage points.