South Carolina's "First in the South" primary ranks among the most important early-state contests. Earlier this month, The Associated Press reported that Biden will also be traveling to the state in May for the state's Democratic Party dinner.

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The vice president is also expected to headline the Michigan Democratic Party's annual Jefferson-Jackson Dinner in Detroit this April. In January, he attended Iowa's inaugural ball in another move some political watchers viewed as a signal he is considering a White House run in 2016.

That said, the Bidens have vacationed in South Carolina before. In 2009, the vice president and his wife spent a weeklong vacation on Kiawah Island.

Biden would be an early favorite in the Democratic field if former Secretary of State Hillary ClintonHillary Rodham ClintonDem rep: 'We must pause the entire Trump agenda' until Russia investigation complete New England Patriots to visit White House on April 19 More than ever, Justice must demand a special prosecutor for Trump-Russia probe MORE opted against another run. The vice president signaled some interest in a bid while campaigning for President Obama’s reelection last fall.

There could also be other political motives behind the vice president's trip. South Carolina is currently in the midst of a special election in the first congressional district that will pit the sister of comedian Stephen Colbert against a still-undetermined Republican candidate. Former Gov. Mark Sanford earned the most votes in the GOP primary earlier this month, but fell short of the majority necessary to secure the Republican nomination.