A quartet of House Republicans eyeing Senate runs were among the 66 Republicans who voted against the bipartisan compromise to increase the debt limit. GOP Reps. Todd Akin (Mo.), Jason ChaffetzJason ChaffetzLet’s not fail in our second chance to protect Bears Ears Trey Gowdy announces retirement from Congress House Oversight slams TSA after report says officials 'interfered' in disciplinary case MORE (Utah), Denny Rehberg (Mont.) and Jeff FlakeJeffrey (Jeff) Lane FlakeMcConnell: 'Whoever gets to 60 wins' on immigration Huckabee Sanders: Dems need to decide if they 'hate' Trump 'more than they love this country' Trump spokeswoman fires back at Flake: 'His numbers are in the tank' MORE (Ariz.) all broke with their party's leadership and opposed the agreement.

Akin is in a contested primary against former Missouri State Treasurer Sarah Steelman, with businessman and longtime Akin donor John Brunner seriously looking into joining the race. Steelman came out in support of an earlier Republican bill that included a balanced-budget amendment. The eventual Republican nominee will face off against Sen. Claire McCaskillClaire Conner McCaskillGovernment watchdog finds safety gaps in assisted living homes GOP Senate candidate fundraising lags behind Dems in key races McCaskill challenger links human trafficking to 'sexual revolution' of 1960s MORE (D-Mo.), who said Monday that while the bill was not perfect, she was "ecstatic about compromise" and that House members would have to "lose their minds" to not pass the bill.

Chaffetz is considering a challenge of longtime Republican Sen. Orrin HatchOrrin Grant HatchOvernight Tech: Uber exec says 'no justification' for covering up hack | Apple considers battery rebates | Regulators talk bitcoin | SpaceX launches world's most powerful rocket Overnight Cybersecurity: Tillerson proposes new cyber bureau at State | Senate bill would clarify cross-border data rules | Uber exec says 'no justification' for covering up breach Hatch introduces bipartisan bill to clarify cross-border data policies MORE (Utah), who has said he is unlikely to vote for the deal in the Senate Tuesday. He has been trying to shore up his conservative bona fides since it became clear he could face a challenge from the right, although Chris Chocola, president of the conservative Club for Growth, indicated to The Hill Monday that Hatch's recent votes won't stop the deep-pocketed group from targeting him.

Rehberg is running against Sen. John Tester (D-Mont.), and Flake is running for the Arizona Senate seat that will be vacated by retiring Sen. John Kyl (R).

Chaffetz and Akin are dependent on their state's Tea Party adherents to win their primaries. Flake is unlikely to face a serious primary, but has taken some centrist stances on immigration that have angered some of the state's conservatives.

Rehberg will likely have a clean shot at Tester in the Republican-leaning state. He said he could not support the plan because it did not include a balanced-budget amendment.