Sen. Scott Brown's (R-Mass.) quip last week about Senate candidate Elizabeth Warren's appearance gave voters a window into Brown's cluelessness, House Minority Leader Nancy Pelosi (D-Calif.) said Sunday on ABC News.

"It really spoke volumes about really disrespect for women that he may not even realize," said Pelosi, who served as the nation's first woman Speaker of the House until Democrats lost control of the chamber in 2010.

Pelosi was responding to a scrap between Brown and Warren, the leading Democratic candidate challenging Brown for his Senate seat, over a nude photo shoot Brown participated in decades ago to help pay for college.

Warren noted in a debate with the other Democratic primary candidates for the seat that she had taken out loans to pay for school and kept her clothes on.

"Thank God," Brown retorted days later during a radio interview.

Brown's joke has incensed women's groups and handed Democrats an opportunity to paint him as disrespectful and sexist. Brown has worked to refocus the discussion on the challenges he overcame in rising out of poverty.

"I hope it's joke-y. And if it is, then hopefully he will take that comment back," Pelosi said. "But women know. They hear a comment like that, it tells you a lot about somebody."

Warren and Brown are in a statistical dead heat, according to a UMass Lowell/Boston Herald poll released Oct. 2. The poll showed Warren leading the field of Democratic candidates vying to take on Brown, who won a special election in 2010 to replace the late Sen. Ted Kennedy (D-Mass.). Brown is now campaigning for his first full term in the Senate.