Republicans have clinched Senate control in an election night that saw Democrats around the country crushed by the growing unpopularity of President Obama.

Democratic losses piled up throughout the night, with the GOP securing a Senate majority before midnight as Sen. Kay HaganKay HaganPolitics is purple in North Carolina Democrats can win North Carolina just like Jimmy Carter did in 1976 North Carolina will be a big battleground state in 2020 MORE lost in North Carolina and Republican Joni Ernst won an open seat in Iowa.

Incumbent Democrats also fell in House and gubernatorial races, adding to the scale of the party's defeat. High-profile Democratic targets including Wisconsin Gov. Scott Walker (R) prevailed, and the party failed to pick up a single Senate seat. 

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The GOP needed to gain six seats to win the majority, and had already gained seven seats before polls even closed in Alaska. There, Republican Dan Sullivan has opened a lead over Sen. Mark BegichMark Peter BegichPerez creates advisory team for DNC transition The future of the Arctic 2016’s battle for the Senate: A shifting map MORE (D) with nearly all of the vote counted. 

Republicans won open seats held by Democrats in Montana, West Virginia, Iowa and South Dakota, and knocked off incumbents in North Carolina, Arkansas and Colorado.

Their majority could grow larger — Sen. Mary LandrieuMary LandrieuYou want to recall John McCain? Good luck, it will be impossible CNN producer on new O'Keefe video: Voters are 'stupid,' Trump is 'crazy' CNN's Van Jones: O'Keefe Russia 'nothingburger' video 'a hoax' MORE (D-La.) will be the underdog in a runoff election in December against Republican Rep. Bill Cassidy. Sen. Mark WarnerMark Robert WarnerTech beefs up lobbying amid Russia scrutiny Overnight Tech: Senate Dems want FCC chief recused from Sinclair merger | Tech rallies on Capitol Hill for DACA | Facebook beefs up lobbying ranks Facebook adds two lobbyists amid Russia probe MORE (D-Va.) was also clinging to a razor-thin lead in Virginia that appeared headed for a recount.

If both Sullivan and Cassidy eventually prevail, that margin could grow to nine seats netted by the GOP by the end of the cycle. 

Sen. Mitch McConnellAddison (Mitch) Mitchell McConnellAlabama election has GOP racing against the clock McConnell PAC demands Moore return its money Klobuchar taking over Franken's sexual assault bill MORE (R-Ky.) easily won his reelection fight, and the other wins ensure he will fulfill his long-held dream of becoming Senate majority leader.

McConnell was declared the victor in his closely watched race as soon as polls closed in the Bluegrass State, defeating Democrat Alison Lundergan Grimes to earn a sixth term. Democrats had early hopes for the Kentucky secretary of State's candidacy, but her campaign couldn't take advantage of the senator's unpopularity in the state. 

McConnell had to wait for several more hours to learn which way Senate control would fall. But the GOP leader's counterpart admitted just before midnight that Democrats had been ushered from power. 

"I'd like to congratulate Senator McConnell, who will be the new Senate Majority Leader. The message from voters is clear: they want us to work together. I look forward to working with Senator McConnell to get things done for the middle class," said now-Senate Majority Leader Harry ReidHarry ReidVirginia was a wave election, but without real change, the tide will turn again Top Lobbyists 2017: Grass roots Boehner confronted Reid after criticism from Senate floor MORE (D-Nev.). 

The change in power means that Obama will spend the last two years of his presidency dealing with an emboldened all-Republican Congress that intends to challenge him on major legislation and, in the words of McConnell, take the country in a “new direction.”

Hagan's loss to state Speaker Thom Tillis was one of the most surprising results of the night, and her fall sealed the Democratic Party's 2014 fate.

Arkansas Sen. Mark PryorMark PryorMedicaid rollback looms for GOP senators in 2020 Cotton pitches anti-Democrat message to SC delegation Ex-Sen. Kay Hagan joins lobby firm MORE (D) was the first incumbent to fall on Tuesday. Freshman Rep. Tom CottonTom CottonCotton: I hope we go back to health care next year Sunday shows preview: GOP gears up for Senate tax reform push A simple way to make America even greater is fixing our patent system MORE (R) handily defeated the centrist lawmaker in a state that has slipped rapidly away from Democrats in recent years.

Colorado Rep. Cory GardnerCory Scott GardnerSenate GOP running out of options to stop Moore Republicans see rising Dem odds in Alabama Cybersecurity pros take first peek at once secretive process behind US hacking toolkit MORE (R) knocked off Sen. Mark UdallMark UdallDemocratic primary could upend bid for Colorado seat Picking 2018 candidates pits McConnell vs. GOP groups Gorsuch's critics, running out of arguments, falsely scream 'sexist' MORE (D), defying Democratic cries that their vaunted ground game would save the vulnerable incumbent. 

Republicans also picked up a Democrat-held open seat in West Virginia with Rep. Shelley Moore CapitoShelley Moore CapitoOvernight Finance: Senate tax bill will include ObamaCare mandate repeal | Stock surge raises pressure for GOP to deliver tax reform | Ryan hints at short-term spending bill | House votes to overhaul federal flood insurance GOP senator: Congress may ‘stumble’ on paying for Trump's infrastructure plan Overnight Tech: Dems want FCC chair investigated over Sinclair merger | Google faces state antitrust probe | Qualcomm rejects Broadcom offer | Startups criticize plan to tax employees' stocks MORE's (R) easy victory. 

South Dakota flipped to the GOP column after former Gov. Mike Rounds (R) won the open seat of retiring Democratic Sen. Tim JohnsonTim JohnsonCourt ruling could be game changer for Dems in Nevada Bank lobbyists counting down to Shelby’s exit Former GOP senator endorses Clinton after Orlando shooting MORE (D). The three-way race had become a late headache for the GOP with the addition of former GOP Sen. Larry Pressler (I), but with Republican attention and help the race turned again in Republicans' favor. 

Rep. Steve Daines (R) then won the open Democratic-held seat in Montana. 

Republican leaders crowed over the victory, arguing voters had sent a strong signal about which party they want in control in Washington.

"The American people have put their trust in the Republican Party, sending a GOP majority to the U.S. Senate. I want to congratulate all our candidates tonight," Republican National Committee Chairman Reince Priebus said in a statement. "Our party's principles and message resonated with voters across the country. This was a rejection of President Obama's failed polices and Harry Reid's dysfunctional Senate."

This post was updated at 5:02 a.m. on November 5.