On the heels of Sen. Mary LandrieuMary Loretta LandrieuLandrieu dynasty faces a pause in Louisiana Senate GOP rejects Trump’s call to go big on gun legislation Project Veritas at risk of losing fundraising license in New York, AG warns MORE's (D-La.) crushing loss in Louisiana Senate, Republicans were quick to tie her defeat to the Democratic Party's heir apparant: Hillary ClintonHillary Diane Rodham ClintonWhat did Peter Strzok do? The strategic blunder of ‘Trump-as-Hitler’ Races to watch in Tuesday’s primaries MORE

Republican National Committee chairman Reince Priebus crowed that Louisianans had “rejected the Democrat agenda and the Obama-Clinton policies that have produced higher healthcare costs and job-killing regulations.”

Sen. Rand PaulRandal (Rand) Howard PaulGOP senators call for probe of federal grants on climate change Overnight Health Care — Presented by the Association of American Medical Colleges — Key ObamaCare groups in limbo | Opioids sending thousands of kids into foster care | House passes bill allowing Medicaid to pay for opioid treatments US watchdog: 'We failed' to stem Afghan opium production MORE (R-Ky.), a likely Republican presidential contender in 2016, also sought to hang the loss around Clinton, the frontrunner for the Democratic nominatio. 

The RNC said its new majority would allow it to pass the “pro-jobs legislation that was stalled in the Senate when Democrats were in control.”

“Bill Cassidy will be a champion for policies that create jobs and grow the economy, especially building the Keystone Pipeline,” Priebus said in a statement. “And as a doctor treating the uninsured, he has seen firsthand how ObamaCare has hurt healthcare in this country and will work toward market-driven, patient-centered reforms. Americans’ priorities will be Republicans’ priorities in the new Senate.”