On the heels of Sen. Mary LandrieuMary LandrieuFive unanswered questions after Trump's upset victory Pavlich: O’Keefe a true journalist Trump’s implosion could cost GOP in Louisiana Senate race MORE's (D-La.) crushing loss in Louisiana Senate, Republicans were quick to tie her defeat to the Democratic Party's heir apparant: Hillary ClintonHillary Rodham ClintonLeBron won't stay at Trump hotel with team Gore: U.S. could switch to popular vote elections ‘Pizzagate’ scare becomes flashpoint in fake news debate MORE

Republican National Committee chairman Reince Priebus crowed that Louisianans had “rejected the Democrat agenda and the Obama-Clinton policies that have produced higher healthcare costs and job-killing regulations.”

Sen. Rand PaulRand PaulGOP rep: Trump has 'extra-constitutional' view of presidency The ignored question: What does the future Republican Party look like? Rand Paul skeptical about Romney as secretary of State MORE (R-Ky.), a likely Republican presidential contender in 2016, also sought to hang the loss around Clinton, the frontrunner for the Democratic nominatio. 

The RNC said its new majority would allow it to pass the “pro-jobs legislation that was stalled in the Senate when Democrats were in control.”

“Bill Cassidy will be a champion for policies that create jobs and grow the economy, especially building the Keystone Pipeline,” Priebus said in a statement. “And as a doctor treating the uninsured, he has seen firsthand how ObamaCare has hurt healthcare in this country and will work toward market-driven, patient-centered reforms. Americans’ priorities will be Republicans’ priorities in the new Senate.”