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Scott Romney, her father and Mitt's older brother, had been mulling a bid. But ruled it out Tuesday night, telling the newspaper that "it just wasn't right for me at this time" and encouraging her to run instead.

Romney McDaniel was active in her uncle's presidential campaign last year. Her mother, Ronna Romney, had two unsuccessful runs for the Senate in the 1990s.

Democrats are favored to hold onto retiring Sen. Carl LevinCarl LevinCongress: The sleeping watchdog Congress must not give companies tax reasons to move jobs overseas A lesson on abuse of power by Obama and his Senate allies MORE's (D-Mich.) seat in the blue-leaning state.