"It's not the right time to put my kids through something like that," she told the paper.
"I'm a stay-at-home mom," Romney McDaniel continued. "My kids do not want me to run, and I said OK. That's what it comes down to."
Republicans who may still be interested in the seat include Reps. Mike Rogers (R-Mich.) and Justin Amash (R-Mich.), as well as former Michigan Secretary of State Terri Lynn Land.
On the Democratic side, Rep. Gary Peters (D-Mich.) and Democratic power broker Debbie Dingell, the wife of Rep. John Dingell (D-Mich.), are both looking into a bid.