Crossroads GPS, the nonprofit arm of GOP strategist Karl Rove's American Crossroads, is targeting four vulnerable Democratic senators on student loans with new Facebook ads charging that the senators are politicizing the issue while the Senate fails to act.

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The group is spending $50,000 on a week of ads attacking Sens. Mark PryorMark PryorMedicaid rollback looms for GOP senators in 2020 Cotton pitches anti-Democrat message to SC delegation Ex-Sen. Kay Hagan joins lobby firm MORE (Ark.), Mark BegichMark Peter BegichPerez creates advisory team for DNC transition The future of the Arctic 2016’s battle for the Senate: A shifting map MORE (Alaska), Mary LandrieuMary LandrieuYou want to recall John McCain? Good luck, it will be impossible CNN producer on new O'Keefe video: Voters are 'stupid,' Trump is 'crazy' CNN's Van Jones: O'Keefe Russia 'nothingburger' video 'a hoax' MORE (La.) and Kay HaganKay HaganLinking repatriation to job creation Former Sen. Kay Hagan in ICU after being rushed to hospital GOP senator floats retiring over gridlock MORE (N.C.) on the issue, all vulnerable red-state Democrats who've come under fire from Crossroads before.

"While even President Obama and the majority of House Members agree on a long-term bipartisan plan to give America's college students relief on their student loans, Sen. Begich voted to put partisan posturing ahead of getting a broadly supported deal done," the ad reads.

It charges that the senator "is holding your future hostage," and that they "broke with moderate Senate colleagues" to help block reform.

"Instead of acting to provide a practical solution to student loan rates, Sen. Begich voted to leave students at the mercy of crass Washington gamesmanship," the ad continues, and urges viewers to call their senator.

Though the Republican-controlled House passed a measure to prevent current student loan rates from doubling on July 1, the Senate was unable to follow suit as their work on immigration reform consumed much of their time before the July 4 recess.

A Democratic-backed fix failed in the upper chamber on Wednesday, unable to gain any Republican support. Senate Republicans are backing a measure sponsored by Sens. Angus KingAngus Stanley KingSenate confirms No. 2 spot at HHS, days after Price resigns Overnight Defense: Mattis offers support for Iran deal | McCain blocks nominees over Afghanistan strategy | Trump, Tillerson spilt raises new questions about N. Korea policy Mattis: Staying in Iran deal is of US national security interest MORE (I-Maine) and Joe ManchinJoseph (Joe) ManchinOvernight Energy: EPA aims to work more closely with industry Overnight Finance: Lawmakers grill Equifax chief over hack | Wells Fargo CEO defends bank's progress | Trump jokes Puerto Rico threw budget 'out of whack' | Mortgage tax fight tests industry clout Lawmakers try again on miners’ pension bill MORE (D-W.Va.) that's similar to the House-passed legislation, but Senate Democrats remain largely opposed to the bill.

Crossroads GPS Communications Director Jonathan Collegio suggested the blame lies on the shoulders not just of Democratic senators who remain opposed to the House bill, but of Senate Majority Leader Harry ReidHarry ReidChris Murphy’s profile rises with gun tragedies Republicans are headed for a disappointing end to their year in power Obama's HHS secretary could testify in Menendez trial MORE (D-Nev.).

"The message here is that not only did Senators Pryor, Begich, Landrieu and Hagan screw up by effectively supporting a massive rate hike on college students, but Harry Reid screwed up by making his members walk the plank on incredibly amateur strategy," he said.

"Harry Reid exposed his caucus to the wrath not only of college students, but of local editorial pages and citizens who value common sense above all. The Senate needs to pass the House plan without delay."

The hike in loan rates has been used as a political bludgeon by both sides in recent weeks, with Democrats charging that the Republican fix would ultimately result in higher loan rates for students.

The potential political fallout of rising rate hikes helped Congress pass a fix last year, amidst a presidential race and urging from both Obama and Republican presidential nominee Mitt Romney, but the path forward this year remains murky.