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The Tea Party-affiliated group is airing two weeks of radio ads attacking the senator in Atlanta, making him their fourth target, alongside Sens. Lindsey GrahamLindsey GrahamDemocrats unnerved by Trump's reliance on generals Graham slams Russia Second Dem calls for probe into Russian election involvement MORE (R-S.C.), Lamar AlexanderLamar AlexanderGOP eyes big gamble on ObamaCare Mnuchin, Price meet with GOP senators Reid bids farewell to the Senate MORE (R-Tenn.) and Richard BurrRichard BurrTop Intel Dem: Congress 'far from consensus' on encryption Trump must be an advocate for the Small Business Administration Dems pledge to fight Sessions nomination MORE (R-N.C.). Like Burr, Isakson isn't up for reelection until 2016.

"Republicans in Congress can stop ObamaCare by refusing to fund it, but Sen. Johnny IsaksonJohnny IsaksonGOP senators wary of nuking filibuster SENATE: Republicans defy odds to keep majority A banner year for U.S. leadership on aid effectiveness MORE refuses to join the fight," the ad intones. "Johnny Isakson voted to give President Obama money to implement ObamaCare earlier this year, and he'll do it again if you don't make your voice heard."

The ad is part of a broader campaign to push Republicans to back Sen. Mike LeeMike LeeSenate sends annual defense bill to Obama's desk Overnight Healthcare: Medical cures bill finally heads to White House Overnight Energy: Trump taps EPA foe to head agency | Energy reform bill officially dead MORE's (R-Utah) campaign to use the impending debate over funding the government to try to force Democrats to defund ObamaCare. So far, 14 GOP senators have signed on, but a number of others have disagreed with the plan.