It attacks members of Congress who "campaign against ObamaCare, while receiving special treatment and thousands in taxpayer subsidies that the rest of us don't get."
The ad will run on conservative talk radio and country music stations in the lawmakers' home bases of Savannah, Atlanta and Athens.
It's an early indication both that Handel is bringing in funds for her bid — at least enough to spend on an early ad buy — and that she plans to make the Affordable Care Act a central attack in her campaign.
Though none of the lawmakers voted for it, Handel appears to be banking on the belief that Georgia voters will see the members as part of the overall problem in Congress that allowed the healthcare law, and other unpopular initiatives of President Obama's, to go forward.
The GOP primary is already crowded, with seven candidates already in, and an eighth, women's basketball team Atlanta Dream co-owner Kelly Loeffler, expected to decide soon whether to run.
A Georgia court recently moved up Georgia's primaries to May 20, nearly two months earlier than normal, giving the candidates in the race less time to increase their name recognition and raise funds for what's likely to be a fierce fight.
Handel's decision to go up early means that fight has already begun.