Wolf alerted press on Monday to his planned announcement, and on Tuesday evening confirmed expectations that he would run as a conservative alternative to Roberts.
In a statement, Wolf, who is a physician and active in conservative Republican politics in Kansas and nationally, focused in on health care as the impetus for his run.
“America’s health care system should not be centered around the government and it should not be centered around doctors. America’s health care system should be centered around patients. I call my plan simply: PatientCare.” he said.
Wolf said he's running to "reclaim the American Dream for all Kansans and all Americans."
Wolf also said, “I am here today to take my stand for America. I’m here today to fight for our Constitution and the divinely-inspired American idea of individual liberty, limited government and free enterprise," he said.
Wolf is Obama's second cousin once removed. He is related to Obama through the president's great-great grandfather, Thomas Creekmore McCurry.
Roberts, who was first elected to the Senate in 1996, won his 2008 election with 60 percent of the vote.
He's a staunch conservative and isn't typically considered vulnerable to conservative attacks, but Wolf has taken issue with Roberts in the past, accusing him of raising the debt ceiling and bailing out Wall Street in an email to GOP activists in August, according to reports.