The widow of Sen. Edward Kennedy (D-Mass.) has ruled out running for her late husband's seat in her strongest words to date.

Vicki Kennedy said she won't run to challenge Sen. Scott Brown (R-Mass.) in 2012, or run for president in the future.

“There will not be a yes," Kennedy told Boston Globe columnist Scot Lehigh on whether she'd agree to run. "The Senate is not where I see my future."

Kennedy's been seen as possibly the strongest candidate Brown could face in 2012, when he'll be heavily targeted for defeat by Democrats. The family's name still carries a great deal of cachet with the state's voters, and the prospect of a member of the Kennedy family entering the race to reclaim the seat the senator had held for more than 46 years would be a game-changer.

Vicki Kennedy said that she had no interest in pursuing elective office, saying that it would be too difficult to run without her husband by her side. The senator had raised the issue a few times, which she had met with dismissal, Vicki Kennedy told the Globe.

Democrats will have to look to other candidates, like members of the state's congressional delegation, to challenge Brown.

The Republican senator has sought to position himself as a centrist in the left-leaning state, and built up a campaign war chest to help him fend off what's expected to be a tough challenge in 2012.