A bomb explosion at a large bus stop in Jerusalem on Wednesday killed one and wounded at least 50 people, The Jerusalem Post reported.

According to media reports, the explosion could be heard throughout Israel's capital city and first responders could be seen removing injured people on stretchers from the scene. 

Israeli authorities told The Post three people were seriously injured. The one fatality was a 59-year-old woman. 

The bus bombing comes about two weeks after Palestinian terrorists killed five members of a Jewish family, including three children, in the West Bank town of Itamar. Militant groups have also continued to fire rockets at Israeli territory from the Hamas-controlled Gaza Strip.

The Israeli Defense Force's response to the rocket attacks from Gaza killed four civilians there on Tuesday, an incident for which Prime Minister Benjamin Netanyahu expressed regret.

The attack also occurred during a stalemate in peace negotiations between the Israelis and Palestinians.

President Obama in a statement condemned the attack, "in the strongest possible terms" and urged both sides to exercise restraint in their response.

"The United States calls on the groups responsible to end these attacks at once and we underscore that Israel, like all nations, has a right to self-defense," he said. "We also express our deepest condolences for the deaths of Palestinian civilians in Gaza yesterday. We stress the importance of calm and urge all parties to do everything in their power to prevent further violence and civilian casualties."

The attack was not a suicide bombing: the device was reportedly placed in a telephone booth near the bus station, according to Ynet News.

Jerusalem experienced widespread attacks on buses and other public places during the Second Intifada, which lasted nearly five years after beginning in 2000. But recently, violence has subsided. The last suicide bombing in Jerusalem occurred in 2004, according to the Associated Press.

-- This post was updated at 11:45 a.m., 12:32 p.m. and 12:42 p.m.