Democrats have a “wide-open playing field” in their bid to take back the House majority, the head of the Democratic Congressional Campaign Committee said Tuesday.

Rep. Steve Israel (D-N.Y.) said Democrats were "in despair" when they lost House control in 2010 but are optimistic they can flip the chamber in 2012.

A key part of winning back the House is hammering Republicans for supporting Budget Committee chairman Paul Ryan's (R-Wis.) 2012 budget plan last week, Israel said.

"We have a wide-open playing field, and we're going to hold Republicans accountable in every single one of those districts," Israel told MSNBC.

In an interview last week with ABC’s “Top Line,” Israel said Democrats would target Republicans who supported the Ryan budget for voting to “terminate” Medicare.

"All we have to do is tell the truth about them," Israel said. “And the truth is in today's vote to terminate the Medicare guaranteed benefit. All we have to do is tell the truth and we'll win the House back."

Israel's comments come the same day the DCCC launched an ad campaign targeting 25 House Republicans for voting for the plan.

The media blitz, which includes radio and online ads as well as recorded and live phone calls, is part of the committee’s "Drive for 25" push in what Democrats see as 25 vulnerable Republican districts.

--This post was updated at 11:46 a.m.

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