Centrist Sen. Olympia Snowe (R-Maine) said Tuesday that she will vote against Rep. Paul RyanPaul Davis RyanMcConnell names Senate GOP tax conferees House Republican: 'I worry about both sides' of the aisle on DACA Overnight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids MORE's (R-Wis.) budget when it comes up for a vote in the Senate.

Snowe, who is up for reelection in 2012, praised Ryan for proposing a budget but said that she disagrees with the way it reforms Medicare.

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"I am going to vote 'no' on the budget because I have deep and abiding concerns about the approach on Medicare, which is essentially to privatize it," Snowe told The Portland Press Herald.

Snowe joins her fellow Maine Sen. Susan CollinsSusan Margaret CollinsOvernight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids Study: ObamaCare bills backed by Collins would lower premiums Right scrambles GOP budget strategy MORE (R) and Massachusetts Sen. Scott Brown (R), each a centrist who has said they will oppose the budget. Like Snowe, Brown faces reelection in 2012. 

Freshman Sen. Rand PaulRandal (Rand) Howard PaulLexington mayor launches bid for Congress Trump-free Kennedy Center Honors avoids politics Meet the Iran hawk who could be Trump's next secretary of State MORE (R-Ky.) has also said he will vote against it, but he says that's because the plan does not go far enough in cutting spending.

Senate Majority Leader Harry ReidHarry ReidBill O'Reilly: Politics helped kill Kate Steinle, Zarate just pulled the trigger Tax reform is nightmare Déjà vu for Puerto Rico Ex-Obama and Reid staffers: McConnell would pretend to be busy to avoid meeting with Obama MORE (D-Nev.) is expected to hold a vote soon, possibly this week, on the plan. The plan is expected to fail, but Reid has said it could elucidate divisions within the Republican Party.

Democrats have seized on Ryan's Medicare plan, criticizing it as an extreme proposal that would privatize the popular, but fiscally troubled, entitlement program. Recently, they have dubbed it the GOP's "litmus test," playing up incidents in which Republicans have split with the plan.

All but four House Republicans voted for Ryan's budget.

Snowe's position is not surprising. She has not praised the Medicare reforms proposed by Ryan, the chairman of the House Budget Committee.

But she also criticized Reid for holding the vote on the Ryan budget, saying it won't foster a true budget debate.

"[Ryan] is not going to have all the answers or the answers that I am going to agree with, but the question is, can we work to improve it, to modify it? But we don't even have the opportunity in the Senate," Snowe said. "That's what we're facing, an up-or-down vote, all or nothing, and it doesn't need to be that way."