Hillary ClintonHillary Rodham ClintonSunday shows preview: Scaramucci makes TV debut as new communication chief OPINION | Dems need a fresh face for 2020: Try Kamala Harris After White House communication team shake up, Trump still tweeting MORE will speak at the McCain Institute's annual Sedona Forum on Saturday with Sen. John McCainJohn McCainSen. Flake's GOP challenger: McCain should resign The Hill's 12:30 Report Armed Services leaders appoint strategy panel members MORE (R-Ariz.), the institute announced Thursday.

In a statement, McCain said he is "very pleased" his "friend" Clinton could join this year's forum.

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"From her years of service as first lady, in the U.S. Senate and at the State Department, one would be hard-pressed to find a leader with Secretary Clinton's informed perspective on the many challenges facing America across the globe," he said.

Both served in the Senate together when Clinton represented New York from 2001 until 2009. She lost the 2008 Democratic primary to President Obama, and he appointed her to be his first secretary of State.

Clinton is now being closely watched to see whether she moves the needle on a potential 2016 presidential bid.

This year's forum focuses on "Crisis in the Middle East: Values, Strategy and Options." Sessions will also cover issues regarding Ukraine and Russia, and combating human trafficking.

Other lawmakers attending the event include Sens. Kelly Ayotte (R-N.H.), Bob Corker (R-Tenn.), Heidi Heitkamp (D-N.D.), Angus King (I-Maine), Amy Klobuchar (D-Minn.) and Sheldon Whitehouse (D-R.I.).

U.S. Deputy Secretary of State Ambassador William Burns, who's retiring later this year, will also attend.

The institute said business leaders, philanthropists, activists and experts on solutions to "real-world problems" will participate in the forum as well.

Last year's Sedona Forum featured remarks from Vice President Biden and six heads of state, among others.