"Today is the day for those folks living in those areas to get away, pack up their stuff and get away," Jindal said.

Jindal had been expected to speak on Tuesday night, the opening night of the convention. He was expected to speak in the middle of a program dominated by popular Republican governors, leading up to New Jersey Gov. Chris Christie's keynote address.

Isaac has already wreaked havoc on the Republican National Convention schedule, forcing organizers to cancel the first day of events and reshuffle the speaking schedule. On Monday, Republican aides said the plan was to press forward with the convention timeline, but they would not rule out additional cancellations or changes.

"We are continuing to go ahead with our program of Tuesday, Wednesday [and] Thursday," Mitt Romney aide Russ Schriefer said at a press conference in Tampa, Fla. "However, we are going to make sure we monitor the storm as it proceeds and see what happens over the next few days."