"Small businesses don't come out of Washington D.C., pre-made on flatbed trucks," McDonnell will say.

McDonnell's remarks are the among the first of what will likely be many mentions at the convention of the president's often panned statement last month during a campaign stop in Roanoke, Va. The first full day of the convention was organized around the theme of "we built it."

Democrats have accused Mitt Romney and his allies of taking the remark out of context.

"If you were successful, somebody along the line gave you some help," Obama said. "There was a great teacher somewhere in your life. Somebody helped to create this unbelievable American system that we have that allowed you to thrive. Somebody invested in roads and bridges. If you've got a business — you didn't build that. Somebody else made that happen. The Internet didn't get invented on its own. Government research created the Internet so that all the companies could make money off the Internet."

McDonnell will also tout the economic successes in some states now governed by Republicans.

"Conservative fiscal policies are working, and so are more Americans in states with Republican governors," he plans to say. "Now, just think what we can do if we had a president who would support us, not obstruct us."