Biden noted that he worked with Helms on the Senate Foreign Relations Committee.
"Jesse Helms worked at the end of his career to deal with AIDS in Africa," Biden continued. "So my point is don't listen to these voices who say compromise is a dirty word. There can be no people further apart ideologically than Strom and I were or Jesse and I were but yet for the good of the nation we were able to make compromise."
Biden's speech rehashed his usual stump attacks on GOP nominee Mitt Romney and vice presidential candidate Paul Ryan. The vice president took aim at Romney for saying that his job was "not to worry about" 47 percent of the country who don't pay income taxes.
"When he said it's not my job to worry about these people, well who's job is it? Ladies and gentlemen we are our brothers' keeper," Biden said. "We are one nation under God. We are all in this together. And if the 47 percent doesn't make it, the country doesn't make it."