"I happen to be in a unique business where winning and losing is the basis of the entire business," Adelson told The Wall Street Journal. "So I don't cry when I lose. There's always a new hand coming up."

Adelson, who reportedly is already being courted by possible 2016 Republican presidential contenders like Virginia Gov. Bob McDonnell and Louisiana Gov. Bobby Jindal, expressed no regret over the $100 million he poured into the campaign.

"I'll spend that much and more," he said. "Let's cut any ambiguity."

In 2012, Adelson was among his party's top donors, liberally giving to the super-PACs of Newt Gingrich and then Mitt Romney. Adelson also donated heavily to outside groups run by the Koch brothers and Karl Rove, other major players in the Republican fundraising scene.

Despite the losses, the casino mogul had praise for both Rove — who "shouldn't take all the blame" — and Romney, whom he declared a "good candidate."

In the same interview Adelson also said he supported the Development, Relief, and Education for Alien Minors (DREAM) Act, favored by Democrats. The legislation offers a pathway to citizenship for illegal immigrants who came to the United States when they were young and then attended college or serve in the military. Although a number of top Republicans have called for passing wide-ranging immigration reform legislation they have continued to oppose the DREAM Act.

"I’m pro-Dream Act, I’m pro the DREAM Act. My parents were immigrants to this  country,” Adelson said.

Adelson said it would be "inhumane" to deport 12 million immigrants living in the country illegally.

“I mean  it’s all ridiculous.  So we’ve  got to find a way, find a route  for those people to get legal citizenship,” Adelson said.

—This story was updated at 9:33 a.m.