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“No — no — you know, nothing against him. You know, he’s very popular. He’s just not one of the guys I listen to,” Rubio said.

When CNN host Jake Tapper quipped that the former 'N Sync member wasn't "hardcore" enough, Rubio laughed.

"Justin Timberlake?" Rubio said. "No."

Rubio has frequently referenced his love of hip-hop in interviews and from the Senate floor. During Sen. Rand PaulRandal (Rand) Howard PaulLexington mayor launches bid for Congress Trump-free Kennedy Center Honors avoids politics Meet the Iran hawk who could be Trump's next secretary of State MORE's (R-Ky.) filibuster earlier this month, Rubio quoted lyrics from Jay-Z and Wiz Khalifa.