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“No — no — you know, nothing against him. You know, he’s very popular. He’s just not one of the guys I listen to,” Rubio said.

When CNN host Jake Tapper quipped that the former 'N Sync member wasn't "hardcore" enough, Rubio laughed.

"Justin Timberlake?" Rubio said. "No."

Rubio has frequently referenced his love of hip-hop in interviews and from the Senate floor. During Sen. Rand PaulRandal (Rand) Howard PaulGOP senator asks to be taken off Moore fundraising appeals Red state lawmakers find blue state piggy bank Prosecutors tell Paul to expect federal charges against attacker: report MORE's (R-Ky.) filibuster earlier this month, Rubio quoted lyrics from Jay-Z and Wiz Khalifa.