“No — no — you know, nothing against him. You know, he’s very popular. He’s just not one of the guys I listen to,” Rubio said.

When CNN host Jake Tapper quipped that the former 'N Sync member wasn't "hardcore" enough, Rubio laughed.

"Justin Timberlake?" Rubio said. "No."

Rubio has frequently referenced his love of hip-hop in interviews and from the Senate floor. During Sen. Rand PaulRandal (Rand) Howard PaulMichael Steele: Congress must lead on cannabis reform and stand with the American public Lawmakers renew call for end to 'black budget' secrecy McCain asks Trump's CIA pick to explain ties to torture MORE's (R-Ky.) filibuster earlier this month, Rubio quoted lyrics from Jay-Z and Wiz Khalifa.