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The Supreme Court on Tuesday heard oral arguments over whether California's ballot initiative banning same-sex marriages in the state was legal. On Wednesday, the court weighed whether to strike down the federal Defense of Marriage Act, which prohibits certain government benefits being granted to same-sex partners.

With the court considering the cases, a flood of lawmakers and political figures — including some Republicans — have voiced support for same-sex marriage. Last week, Sen. Rob PortmanRob PortmanGOP senators bristle at Trump's Medicaid cuts Overnight Energy: Trump budget takes flak over oil provisions GOP senators knock Trump's budget proposal MORE (R-Ohio) said he had changed his stance on the issue after his own son came out to him.

In the interview, Huckabee says he has "great sympathy and extraordinary admiration" for Portman, but believes he erred in changing his mind.

"The mistake is that we sometimes base our public policy decisions on how we feel, how we think, maybe even some personal experiences, and we don’t regard a lot of these issues from the standpoint of an objective standard," Huckabee said.