The immigration reform proposal backed by a bipartisan group of senators can't be compared to President Obama's healthcare reform law, said Sen. Marco RubioMarco Antonio RubioRyan pledges 'entitlement reform' in 2018 Richard Gere welcomes lawmakers' words of support for Tibet Dem lawmaker gives McConnell's tax reform op-ed a failing grade MORE (R-Fla.), one of senators that introduced the proposal argued Tuesday.

"First of all, ObamaCare, you can't compare the two," Rubio said in an interview on "The Michael Medved Show." "ObamaCare created a brand-new entitlement program in America. It got the government in the business of health insurance, which it has no business in being a part of."

Some critics of the immigration reform proposal have cited the healthcare law in arguing against passage of the immigration reform bill. Sen. Mike LeeMichael (Mike) Shumway LeeSupreme Court takes on same-sex wedding cake case House approves motion to go to tax conference — with drama Trump really will shrink government, starting with national monuments MORE (R-Utah) called the reform bill "an immigration version of ObamaCare."

Rubio said the federal government has no business in healthcare but it does need to participate in immigration laws.

"If you listen carefully to conservative arguments and criticisms — not just of this bill but of the status quo on immigration — the criticism is that the government's not doing enough because this is a fundamental obligation of the government: not doing enough to secure the border, not doing enough to deport people who are here illegally, not doing enough to put in place a system to verify those that are here," Rubio said.

"So I think there's a fundamental misunderstanding between the difference between ObamaCare, which is an expansion of the government's role into something it has no business being part of, and border security and immigration law which is a fundamental obligation, constitutional obligation of the federal government," Rubio continued.

Rubio's comments took place a few days after the Senate voted to end debate on the bill in a vote of 67-27. Senate Majority Leader Harry ReidHarry ReidBill O'Reilly: Politics helped kill Kate Steinle, Zarate just pulled the trigger Tax reform is nightmare Déjà vu for Puerto Rico Ex-Obama and Reid staffers: McConnell would pretend to be busy to avoid meeting with Obama MORE (D-Nev.) wants to pass the immigration bill out of his chamber before the Senate goes on its July recess.