House Speaker Paul RyanPaul RyanRyan: Graham-Cassidy 'best, last chance' to repeal ObamaCare Ryan: Americans want to see Trump talking with Dem leaders Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea MORE (R-Wis.) says he isn't concerned over Donald TrumpDonald John TrumpBiden slams Trump over golf gif hitting Clinton Trump Jr. declines further Secret Service protection: report Report: Mueller warned Manafort to expect an indictment MORE's potential conflicts of interest and is confident the president-elect will separate them from his business.

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"I have every bit of confidence he's going to get himself right with moving himself from the business guy that he is to the president he's going to be," Ryan on Wednesday told CNBC's "Squawk Box."

Asked how Trump should address the conflicts of interest, Ryan responded, "However he wants to."

"This is not what I'm concerned about in Congress. ... I'm focused on getting this agenda passed so that we can turn around and tackle this country's big problems before they tackle us. That is what I'm focused on and not the legal details of how he divorces himself from his business, which I know he will," he added.

Critics have questioned how Trump will deal with potential conflicts of interest since his election. A new poll released Wednesday, though, showed that almost 70 percent of Americans had no problem with Trump keeping his business.

Last week, the president-elect said that he would be "leaving (his) great business in order to fully focus on running the country in order to make America great again."

"While I am not mandated to do this under the law, I feel it is visually important, as President, to in no way have a conflict of interest with my various businesses," Trump tweeted. "Hence, legal documents are being crafted which take me completely out of business operations. The Presidency is a far more important task!"