Sen. John McCainJohn Sidney McCainSenate's defense authorization would set cyber doctrine Senate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Overnight Defense: Senate passes 0B defense bill | 3,000 US troops heading to Afghanistan | Two more Navy officials fired over ship collisions MORE (R-Ariz) on Friday said Sens. Ted CruzRafael (Ted) Edward CruzSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea GOP state lawmakers meet to plan possible constitutional convention MORE (Texas) and Rand PaulRandal (Rand) Howard PaulSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Overnight Defense: Senate passes 0B defense bill | 3,000 US troops heading to Afghanistan | Two more Navy officials fired over ship collisions Lawmakers grapple with warrantless wiretapping program MORE (Ky.) would be viable presidential nominees for the GOP in 2016.

McCain has had dustups with the two conservative firebrands throughout the year, at one point colorfully labeling them "wacko birds." 

Both Cruz and Paul are eyeing runs for the White House in 2016, and would have a real shot if nominated, according to McCain.

“If that is who the party chooses I am sure that that nominee will be viable,” he said in an interview with ABC published Friday.

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McCain warned, however, that any GOP candidate would founder in a general election if immigration reform stalls in Congress. Both Cruz and Paul voted against a comprehensive immigration reform bill in the Senate earlier this year. 

“I want to say in the strongest possible terms that if we fail on immigration reform, it won’t matter who our nominee is because of the polarization of the Hispanic vote,” he said. 

He also had some advice for Cruz, who earlier in the week claimed some GOP colleagues had not signed onto his proposal to tie a deal to avert a government shutdown to the defunding of ObamaCare because they were “scared” of being beaten up politically.

McCain said he has seen his share of partisan battles but tries to keep his attacks tied to issues. He said Republicans should be aware of how they treat their colleagues. 

“Look, I have been as ferocious a fighter and I think as partisan as anybody but I really try hard not to get personal,” he said. “Debate on the issue as hard as you can but don’t say your opponents, the people who disagree with you, are scared. It has been a long time since I’ve been scared.”