Former Democratic presidential candidate Sen. Bernie SandersBernie SandersOvernight Finance: Dems introduce minimum wage bill | Sanders clashes with Trump budget chief | Border tax proposal at death's door Sanders, Democrats introduce minimum wage bill Live coverage: Political world turns to Montana special election MORE (I-Vt.) on Friday released an Inauguration Day message urging supporters to “fight back” against Donald TrumpDonald TrumpDNC calls for suspension of Kushner's security clearance amid FBI scrutiny Reporter assaulted by GOP candidate: Most 'surreal experience' of my career Lawyer: Kushner to cooperate on all probes of Russia meetings MORE's agenda.

“Today is going to be a tough day for millions of Americans, including myself,” Sanders said in a video posted on Twitter. “But our response has got to be not to throw up our hands in despair — not to give up — but in fact to fight back as effectively and as vigorously as we can.

“And our job is to keep our eyes on the prize, and the prize is that we will continue fighting for a government that represents all of us; not just the 1 percent,” he continued. “And we are going to go forward, in the fight for economic, social, environmental and racial justice. That’s who we are, that’s what we are going to do. We are not giving up.”

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Sanders’s comments were posted just hours before Trump was set to take the Oath of Office.

The Vermont senator gained a sizable following among progressive Democrats during the 2016 primaries with his critique of economic and social inequality in the U.S., but eventually lost the primaries to Hillary ClintonHillary Rodham ClintonEx-Clinton aide rips Russia for using her name in documents Sanders, Democrats introduce minimum wage bill Fox News: 'Foolish' to think Hannity won't return MORE.

Sanders has said in recent weeks that he sees opportunities to work with Trump, particularly on job creation and a plan to overhaul the nation’s crumbling infrastructure. Still, he has not shied away from criticizing the president-elect, and has vowed to oppose him on a number of issues, such as climate change, which Trump has called a “hoax.”'

Some protesters took to the streets of Washington ahead of Trump's inauguration. Bigger protests are expected on Saturday.