Former Democratic presidential candidate Sen. Bernie SandersBernard (Bernie) SandersSanders, Warren, O’Rourke inspire patriotic small donor waves Bill Press reflects on Clinton, Sanders and a life in politics Overnight Health Care: GOP pushes stiff work requirements for food stamps | Johnny Isakson opens up about family's tragic loss to opioids | Republicans refuse to back vulnerable Dem's opioids bill | Dems offer new public option plan MORE (I-Vt.) on Friday released an Inauguration Day message urging supporters to “fight back” against Donald TrumpDonald John TrumpHouse Republicans push Mulvaney, Trump to rescind Gateway funds Pruitt spent K flying aides to Australia to prep for later-canceled visit: report Rosenstein told Trump he is not a target of Mueller probe: report MORE's agenda.

“Today is going to be a tough day for millions of Americans, including myself,” Sanders said in a video posted on Twitter. “But our response has got to be not to throw up our hands in despair — not to give up — but in fact to fight back as effectively and as vigorously as we can.

“And our job is to keep our eyes on the prize, and the prize is that we will continue fighting for a government that represents all of us; not just the 1 percent,” he continued. “And we are going to go forward, in the fight for economic, social, environmental and racial justice. That’s who we are, that’s what we are going to do. We are not giving up.”

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Sanders’s comments were posted just hours before Trump was set to take the Oath of Office.

The Vermont senator gained a sizable following among progressive Democrats during the 2016 primaries with his critique of economic and social inequality in the U.S., but eventually lost the primaries to Hillary ClintonHillary Diane Rodham ClintonJustice to provide access to Comey memos to GOP lawmakers Justice Dept inspector asks US attorney to consider criminal charges for McCabe: reports 'Homeland' to drop Trump allegories in next season MORE.

Sanders has said in recent weeks that he sees opportunities to work with Trump, particularly on job creation and a plan to overhaul the nation’s crumbling infrastructure. Still, he has not shied away from criticizing the president-elect, and has vowed to oppose him on a number of issues, such as climate change, which Trump has called a “hoax.”'

Some protesters took to the streets of Washington ahead of Trump's inauguration. Bigger protests are expected on Saturday.