A super PAC with ties to Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellLawmakers feel pressure on guns Bipartisan group of House lawmakers urge action on Export-Import Bank nominees Curbelo Dem rival lashes out over immigration failure MORE (R-Ky.) is targeting Sen. Joe ManchinJoseph (Joe) ManchinPavlich: The claim Trump let the mentally ill get guns is a lie Toomey to introduce bill broadening background checks for firearms Scott Walker backs West Virginia attorney general in GOP Senate primary MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Diane Rodham ClintonWoman behind pro-Trump Facebook page denies being influenced by Russians Trump: CNN, MSNBC 'got scammed' into covering Russian-organized rally Pennsylvania Democrats set to win big with new district map MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampMary (Heidi) Kathryn HeitkampSenate rejects Trump immigration plan Cramer to announce North Dakota Senate run on Friday Senate Democrats not sold on bipartisan immigration deal MORE (N.D.), Claire McCaskillClaire Conner McCaskillMcCaskill welcomes ninth grandson in a row Dem group launches M ad buy to boost vulnerable senators Senate Dems block crackdown on sanctuary cities MORE (Mo.) and Joe DonnellyJoseph (Joe) Simon DonnellyDemocrats now attack internet rules they once embraced Dem group launches M ad buy to boost vulnerable senators Senate rejects Trump immigration plan MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.