A super PAC with ties to Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellGOP strategist donates to Alabama Democrat McConnell names Senate GOP tax conferees Brent Budowsky: A plea to Alabama voters MORE (R-Ky.) is targeting Sen. Joe ManchinJoseph (Joe) ManchinTrump rips Dems a day ahead of key White House meeting Senate panel moves forward with bill to roll back Dodd-Frank Wealthy outsiders threaten to shake up GOP Senate primaries MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Diane Rodham ClintonGrassley blasts Democrats over unwillingness to probe Clinton GOP lawmakers cite new allegations of political bias in FBI Top intel Dem: Trump Jr. refused to answer questions about Trump Tower discussions with father MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampMary (Heidi) Kathryn HeitkampThe Hill's 12:30 Report Avalanche of Democratic senators say Franken should resign Senate panel moves forward with bill to roll back Dodd-Frank MORE (N.D.), Claire McCaskillClaire Conner McCaskillDemocrats turn on Al Franken Trump rips Dems a day ahead of key White House meeting The Hill's 12:30 Report MORE (Mo.) and Joe DonnellyJoseph (Joe) Simon DonnellyTrump rips Dems a day ahead of key White House meeting The Hill's 12:30 Report Avalanche of Democratic senators say Franken should resign MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.