A super PAC with ties to Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellGOP moves to cut debate time for Trump nominees McConnell hits back at 'ridiculous' Chinaperson remark GOP senator: 'We were there' on immigration before talks got derailed MORE (R-Ky.) is targeting Sen. Joe ManchinJoseph (Joe) ManchinMcConnell hits back at 'ridiculous' Chinaperson remark Overnight Defense: New allegations against VA nominee | Pompeo vote set for Thursday | Work begins on defense policy bill | Measures push space corps, pay bump for troops Pompeo set to be confirmed on Thursday MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Diane Rodham ClintonKim Kardashian West defends Kanye on Trump: 'He's a free thinker, is that not allowed?' Trump comments on Fifth Amendment resurface after Cohen filing The 'Handmaid's Tale' liberal feminists created MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampMary (Heidi) Kathryn HeitkampOvernight Defense: New allegations against VA nominee | Pompeo vote set for Thursday | Work begins on defense policy bill | Measures push space corps, pay bump for troops Pompeo set to be confirmed on Thursday Election security dominates hearing for Trump Homeland Security nominee MORE (N.D.), Claire McCaskillClaire Conner McCaskillOvernight Cybersecurity: DHS cyber nominee vows to make election security 'top priority' | CIA to allow lawmakers to review classified info on Haspel | Dems raise security concerns about Trump's phone use Election security dominates hearing for Trump Homeland Security nominee Overnight Cybersecurity: Homeland Security official says Russia likely targeted more than 21 states | Senate approves Trump's NSA chief | Lawmakers unveil bipartisan internet privacy bill MORE (Mo.) and Joe DonnellyJoseph (Joe) Simon DonnellyOvernight Defense: New allegations against VA nominee | Pompeo vote set for Thursday | Work begins on defense policy bill | Measures push space corps, pay bump for troops Pompeo set to be confirmed on Thursday Schumer to oppose Pompeo as secretary of State MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.