A super PAC with ties to Senate Majority Leader Mitch McConnellMitch McConnellRepublicans give Trump's budget the cold shoulder Senate GOP focused on killing Medicaid expansion Hearing highlights GOP divide over border tax MORE (R-Ky.) is targeting Sen. Joe ManchinJoe ManchinDem senator: UK attack shows importance of US intelligence community Heitkamp, Manchin under pressure over GOP regs bill Dem senator: Mueller ‘great choice’ to lead Russia probe MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Rodham ClintonHannity: I won't discuss Seth Rich story for now "out of respect for the family" Clinton slams Trump's budget: 'An unimaginable level of cruelty' Trump’s crisis of legitimacy MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampHeidi HeitkampSeparating fact from fiction in the Regulatory Accountability Act Heitkamp, Manchin under pressure over GOP regs bill Overnight Energy: Senate panel advances regulatory reform bills MORE (N.D.), Claire McCaskillClaire McCaskillTechnology's role in human trafficking cannot be ignored Five things to know about Joe Lieberman Senate GOP short on ideas for stabilizing ObamaCare markets MORE (Mo.) and Joe DonnellyJoe DonnellyUpdated fuel regulations would modernize options at gas pumps Mnuchin mum as Dems press for answers on tax reform, Dodd-Frank Overnight Defense: Senate passes funding bill | Trump to get Afghan war plan next week | Concerns grow over Army nominee MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.