Brown crossed the aisle after Majority Leader Harry Reid (D-Nev.) nixed an $85 billion, bipartisan plan in favor of a more narrowly-focused bill.
Democrats needed to poach Brown and and least one other Republican to reach the 60 votes necessary. Centrist Republican Sens. Susan Collins (Maine) and Olympia Snowe (Maine) also voted for cloture on the proposal.
Reitiring GOP Sens. George Voinovich (Ohio) and Kit Bond (R-Mo.) also voted for cloture.
Brown was elected to the Senate with the backing of conservatives largely because of his pledge to serve as the 41st vote to uphold a filibuster of the Democrats health reform bill.
But Brown has expressed a willingness to work with Democrats on other issues.