Caroline Kennedy is interested in filling Sen. Hillary Rodham Clinton's (D-N.Y.) seat once Clinton becomes secretary of State, according to multiple news outlets.

Kennedy, the daughter of President John F. Kennedy and a campaign aide to President-elect Barack ObamaBarack ObamaSpicer: Trump is 'very confident that he will be vindicated' on surveillance claims Bush DHS secretary: 'Vladimir Putin is winning' Trump ally calls for US to roll back climate commitment MORE, has talked to New York Gov. David Paterson (D) about the vacant post, according to ABC News sources. New York State Democratic sources told NBC News that Kennedy has indicated her interest in being appointed to the seat, which was once held by her uncle, Robert F. Kennedy (D).

Another Kennedy, Robert F. Kennedy Jr., has taken himself out of the running, according to NBC's Andrea Mitchell. Other Democrats mentioned for the spot include New York Attorney General Andrew Cuomo, Rep. Kirsten Gillibrand, Buffalo Mayor Byron Brown, Rep. Brian Higgins and Rep. Nydia Velazquez.

Though appointing Caroline Kennedy wouldn't appear to directly help Paterson with upstate voters he needs for reelection in 2010, she could help him win access to the White House and national donors, according to Senate Guru. Kennedy, along with Sen. Edward Kennedy (D-Mass.), endorsed Obama early on in the Democratic nomination fight. She was also a member of his vice presidential selection committee.