This story from Kevin Bogardus and this post from Mike have major consequences:
Sen. Arlen Specter (R-Pa.) announced Tuesday he will not vote for cloture on card-check, giving an apparent death blow to the most important congressional issue to organized labor.

It is worth noting, of course, that Specter is facing another primary challenge from Former Rep. Pat Toomey. Many political observers will say Specter's announcement is politically motivated even though Specter dismissed that criticized during the floor statement.