Prior to the vote on passage, which is set for after 4 p.m., the upper chamber will engage in five-hours of debate and votes on three amendments that pertain to the legislation. 

The most controversial amendment of the three is sponsored by Sen. Tom CoburnTom CoburnAl Franken: 'I make fun of the people who deserved it' The more complex the tax code, the more the wealthy benefit Congress, stop using our nation's military policy for political purposes MORE (R-Okla.) and in effect would prohibit the federal government from using funds raised through patent fees for unrelated purposes.

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 The House already rejected similar language contained in that amendment, and earlier in the day Sen. Patrick LeahyPatrick LeahyImmigration battlefield widens for Trump, GOP Grassley shouldn't allow Senate Democrats to block judicial nominees Trump’s rhetoric and bluster could lose US an ally in Mexico MORE (D-Vt.), who is the floor manager for the patent bill, said its additon would likely “kill” patent reform efforts.

The other two amendments offered by Sens. Jeff SessionsJefferson (Jeff) SessionsFBI opens tip line requesting information on Charlottesville rally Sessions rails against Chicago during visit to Miami DOJ warrant of Trump resistance site triggers alarm MORE (R-Ala.) and Maria CantwellMaria Elaine CantwellDemocrats demand changes to FCC Republican nominee's confirmation Bipartisanship? It's happening to secure America's energy future Senate confirms Trump's nominee for No. 2 Interior post MORE (D-Wash.), pertain to patent term extensions and a transitional program for covered business method patents, respectively.

Before adjourning the Senate at about 8 p.m. Reid also outlined the schedule for the rest of the week saying the Senate would move to a procedural vote on a joint resolution of disapproval of the president’s exercise of authority to increase the debt limit. That vote will occur after President Obama delivers his "jobs" speech to a joint session of Congress on Thursday night.

Reid said if that resolution is taken up he might hold the Senate open “for a long time” on Friday to "dispose" of it.

The Senate is set to return at 9:30 a.m. on Thursday.