Prior to the vote on passage, which is set for after 4 p.m., the upper chamber will engage in five-hours of debate and votes on three amendments that pertain to the legislation. 

The most controversial amendment of the three is sponsored by Sen. Tom CoburnThomas (Tom) Allen CoburnMr. President, let markets help save Medicare Pension insolvency crisis only grows as Congress sits on its hands Paul Ryan should realize that federal earmarks are the currency of cronyism MORE (R-Okla.) and in effect would prohibit the federal government from using funds raised through patent fees for unrelated purposes.

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 The House already rejected similar language contained in that amendment, and earlier in the day Sen. Patrick LeahyPatrick Joseph LeahyDem senator mocks Pruitt over alleged security threats: 'Nobody even knows who you are' Pruitt tells senators: ‘I share your concerns about some of these decisions’ Protesters hold up 'fire him' signs behind Pruitt during hearing MORE (D-Vt.), who is the floor manager for the patent bill, said its additon would likely “kill” patent reform efforts.

The other two amendments offered by Sens. Jeff SessionsJefferson (Jeff) Beauregard SessionsDeVos grilled on civil rights for students House conservatives introduce resolution calling for second special counsel The Hill's Morning Report — Sponsored by PhRMA — How long can a Trump-DOJ accord survive? MORE (R-Ala.) and Maria CantwellMaria Elaine CantwellHillicon Valley: Lawmakers target Chinese tech giants | Dems move to save top cyber post | Trump gets a new CIA chief | Ryan delays election security briefing | Twitter CEO meets lawmakers Twitter CEO meets with lawmakers to talk net neutrality, privacy Senate Dems urge Trump to remain in Iran deal ahead of announcement MORE (D-Wash.), pertain to patent term extensions and a transitional program for covered business method patents, respectively.

Before adjourning the Senate at about 8 p.m. Reid also outlined the schedule for the rest of the week saying the Senate would move to a procedural vote on a joint resolution of disapproval of the president’s exercise of authority to increase the debt limit. That vote will occur after President Obama delivers his "jobs" speech to a joint session of Congress on Thursday night.

Reid said if that resolution is taken up he might hold the Senate open “for a long time” on Friday to "dispose" of it.

The Senate is set to return at 9:30 a.m. on Thursday.