Prior to the vote on passage, which is set for after 4 p.m., the upper chamber will engage in five-hours of debate and votes on three amendments that pertain to the legislation. 

The most controversial amendment of the three is sponsored by Sen. Tom CoburnTom CoburnCoburn: Trump's tweets aren't presidential The road ahead for America’s highways Rethinking taxation MORE (R-Okla.) and in effect would prohibit the federal government from using funds raised through patent fees for unrelated purposes.

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 The House already rejected similar language contained in that amendment, and earlier in the day Sen. Patrick LeahyPatrick LeahyJustice, FBI to be investigated over Clinton probes Sessions: Grabbing a woman's genitals without consent is sexual assault Live coverage of Sessions confirmation hearing MORE (D-Vt.), who is the floor manager for the patent bill, said its additon would likely “kill” patent reform efforts.

The other two amendments offered by Sens. Jeff SessionsJeff SessionsMega-mergers poised to get green light under Trump WHIP LIST: How many Dems will back Sessions? Loretta Lynch: ‘You’ve got to hold police accountable’ MORE (R-Ala.) and Maria CantwellMaria CantwellDems seek more vetting for Trump nominees before hearings Four Washington electors refuse to vote for Clinton Dems concerned Trump trying to 'target' Energy Dept. employees MORE (D-Wash.), pertain to patent term extensions and a transitional program for covered business method patents, respectively.

Before adjourning the Senate at about 8 p.m. Reid also outlined the schedule for the rest of the week saying the Senate would move to a procedural vote on a joint resolution of disapproval of the president’s exercise of authority to increase the debt limit. That vote will occur after President Obama delivers his "jobs" speech to a joint session of Congress on Thursday night.

Reid said if that resolution is taken up he might hold the Senate open “for a long time” on Friday to "dispose" of it.

The Senate is set to return at 9:30 a.m. on Thursday.