Many of the 25 amendments up for consideration Wednesday seek to exempt certain regulations from the bill. But on the strength of Republican opposition, the first five were defeated in roll call votes:

• Alcee Hastings (D-Fla.), to provide an exception to the underlying legislation, permitting agencies to make regulatory actions intended to ensure safe drinking water. Failed 188-231.

• Hank Johnson (D-Ga.), to exempt regulatory actions pertaining to privacy from Title I of the bill and exempts midnight rules pertaining to privacy from Title II of the bill. The amendment would also exempt consent decrees and settlement agreements in an action to compel agency action pertaining to privacy from Title III of the bill. Failed 159-259.

• Dennis Kucinich (D-Ohio), to exempt from the provisions of the bill any significant regulatory action specifically aimed at limiting oil speculation. Failed 173-245.

Peter WelchPeter WelchTrump talks tough but little action seen on drug prices Frustrated with Trump, Dems introduce drug pricing bill Lawmakers try again on miners’ pension bill MORE (D-Vt.), to provide an exception from the bill for regulations which are intended to promote energy efficiency. Failed 174-242.

Ed MarkeyEdward (Ed) John MarkeyCBS series 'Madam Secretary' exploring 'fake news' plot Senate Dems warn against cutting ObamaCare fund to pay for children's health program Trump’s North Korea strategy requires an intervention from Congress MORE (D-Mass.), to exempt from the bill regulations protecting the public from extreme weather, including drought, flooding and catastrophic wildfire. Failed 177-240.