Many of the 25 amendments up for consideration Wednesday seek to exempt certain regulations from the bill. But on the strength of Republican opposition, the first five were defeated in roll call votes:

• Alcee Hastings (D-Fla.), to provide an exception to the underlying legislation, permitting agencies to make regulatory actions intended to ensure safe drinking water. Failed 188-231.

• Hank Johnson (D-Ga.), to exempt regulatory actions pertaining to privacy from Title I of the bill and exempts midnight rules pertaining to privacy from Title II of the bill. The amendment would also exempt consent decrees and settlement agreements in an action to compel agency action pertaining to privacy from Title III of the bill. Failed 159-259.

• Dennis Kucinich (D-Ohio), to exempt from the provisions of the bill any significant regulatory action specifically aimed at limiting oil speculation. Failed 173-245.

Peter WelchPeter WelchA bipartisan consensus against 'big pharma' is growing in Congress Dems push leaders to talk less about Russia House Dems slam Trump's 'betrayal' on drug pricing MORE (D-Vt.), to provide an exception from the bill for regulations which are intended to promote energy efficiency. Failed 174-242.

Ed MarkeyEd MarkeySenators urge Trump to do right thing with arms sales to Taiwan Dems push for more action on power grid cybersecurity Dem senator: Trump 'doesn't respect' the presidency MORE (D-Mass.), to exempt from the bill regulations protecting the public from extreme weather, including drought, flooding and catastrophic wildfire. Failed 177-240.