Many of the 25 amendments up for consideration Wednesday seek to exempt certain regulations from the bill. But on the strength of Republican opposition, the first five were defeated in roll call votes:

• Alcee Hastings (D-Fla.), to provide an exception to the underlying legislation, permitting agencies to make regulatory actions intended to ensure safe drinking water. Failed 188-231.

• Hank Johnson (D-Ga.), to exempt regulatory actions pertaining to privacy from Title I of the bill and exempts midnight rules pertaining to privacy from Title II of the bill. The amendment would also exempt consent decrees and settlement agreements in an action to compel agency action pertaining to privacy from Title III of the bill. Failed 159-259.

• Dennis Kucinich (D-Ohio), to exempt from the provisions of the bill any significant regulatory action specifically aimed at limiting oil speculation. Failed 173-245.

Peter WelchPeter WelchTrump to continue paying ObamaCare subsidies House Democrats call for revoking Kushner’s security clearance Pelosi seeks to unify Dems on ObamaCare fixes MORE (D-Vt.), to provide an exception from the bill for regulations which are intended to promote energy efficiency. Failed 174-242.

Ed MarkeyEd MarkeyOvernight Energy: Trump set to sign offshore drilling order Sanders: Trump couldn't be 'more wrong' on climate Overnight Cybersecurity: Ex-officials warn 'Buy American' might harm Pentagon cybersecurity | Chair nudges Trump on cyber order | House gets security training MORE (D-Mass.), to exempt from the bill regulations protecting the public from extreme weather, including drought, flooding and catastrophic wildfire. Failed 177-240.