Many of the 25 amendments up for consideration Wednesday seek to exempt certain regulations from the bill. But on the strength of Republican opposition, the first five were defeated in roll call votes:

• Alcee Hastings (D-Fla.), to provide an exception to the underlying legislation, permitting agencies to make regulatory actions intended to ensure safe drinking water. Failed 188-231.

• Hank Johnson (D-Ga.), to exempt regulatory actions pertaining to privacy from Title I of the bill and exempts midnight rules pertaining to privacy from Title II of the bill. The amendment would also exempt consent decrees and settlement agreements in an action to compel agency action pertaining to privacy from Title III of the bill. Failed 159-259.

• Dennis Kucinich (D-Ohio), to exempt from the provisions of the bill any significant regulatory action specifically aimed at limiting oil speculation. Failed 173-245.

Peter WelchPeter WelchDem lawmakers propose bill to regulate drone data collection Cummings: Trump commits to strong push for Medicare drug price negotiation Top Oversight Dem to meet with Trump about prescription drug prices MORE (D-Vt.), to provide an exception from the bill for regulations which are intended to promote energy efficiency. Failed 174-242.

Ed MarkeyEd MarkeyThe Hill’s Whip List: Where Dems stand on Trump’s Supreme Court nominee Overnight Regulation: Senate moves to strike Obama-era internet privacy rules Overnight Tech: Senate votes to eliminate Obama internet privacy rules | FCC chief wants to stay out of 'political debate' on fake news | Wikileaks reveals new CIA docs MORE (D-Mass.), to exempt from the bill regulations protecting the public from extreme weather, including drought, flooding and catastrophic wildfire. Failed 177-240.