Forty-three GOP senators on Saturday signed a letter addressed to Senate Majority Leader Harry ReidHarry ReidBill O'Reilly: Politics helped kill Kate Steinle, Zarate just pulled the trigger Tax reform is nightmare Déjà vu for Puerto Rico Ex-Obama and Reid staffers: McConnell would pretend to be busy to avoid meeting with Obama MORE (D-Nev.) expressing opposition to his debt-ceiling legislation currently being considered in the upper chamber.

Their unified opposition to the bill leaves Democrats at least three votes short of the 60 needed to a clear cloture and virtually assures its defeat when it comes up for a vote tonight or tomorrow morning.

Only moderate Republican Sens. Susan CollinsSusan Margaret CollinsOvernight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids Study: ObamaCare bills backed by Collins would lower premiums Right scrambles GOP budget strategy MORE (Maine), Olympia Snowe (Maine), Scott Brown (Mass.) and Lisa MurkowskiLisa Ann MurkowskiMcConnell names Senate GOP tax conferees Week ahead: Trump expected to shrink two national monuments GOP on verge of opening Arctic refuge to drilling MORE (Alaska) did not sign on to the letter.

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"We are writing to let you know that we will not vote for your $2.4 trillion debt limit amendment which, if enacted, would result in the single largest debt ceiling increase in the history of the United States," reads the letter.

Senate Minority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellGOP strategist donates to Alabama Democrat McConnell names Senate GOP tax conferees Brent Budowsky: A plea to Alabama voters MORE (R-Ky.) took to the floor moments after the letter was delivered to assure Reid, who was also on the floor, that the proposal had no chance of clearing the chamber.

"It’s not going anywhere," said McConnell. "It will not pass the Senate. It will not pass House."

McConnell also accused Reid of "delaying the inevitable" defeat of the bill and called for an immediate vote. The first procedural vote is currently expected at around 1 a.m. on Sunday. 

Reid responded to the news of the letter, which he apparently received while he was on the floor, by asking McConnell what Republicans would agree to since they oppose his plan.

"What will they vote for?" asked Reid. "Do they have any ideas? Let me know.”

The Reid plan would have President Obama request a $2.4 trillion debt-limit increase in two installments of $1.2 trillion each. The requests would be subject to congressional resolutions of disapproval.