The Senate starts at 10 a.m. on Thursday and will vote at 1:45 p.m. to confirm Sylvia Burwell to head the Department of Health and Human Services (HHS).
On Wednesday, the Senate easily advanced her nomination in a 67-28 vote, with 14 Republicans joining Democrats to end debate.
But some Republicans, such as Sen. David Vitter (R-La.), have said they'd oppose her nomination as a protest against ObamaCare, which she will be responsible for managing once she takes the place of outgoing Secretary Kathleen Sebelius.
The Senate will also vote on the nomination of Carolyn Hessler Radelet to be director of the Peace Corps before adjourning for the week.
The House is not in session this week.